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Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy?

Metabolic syndrome and cardiomyopathies are long-term consequences of chemo- and radiotherapy and develop long after completing the initial tumor treatment. The slow progression of such late effects might be an indication of the involvement of autoimmune processes in the development of such follow-u...

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Autores principales: Haberland, Annekathrin, Santos, Robson A.S., Schimke, Ingolf, Wallukat, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618042/
https://www.ncbi.nlm.nih.gov/pubmed/23569443
http://dx.doi.org/10.1159/000348425
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author Haberland, Annekathrin
Santos, Robson A.S.
Schimke, Ingolf
Wallukat, Gerd
author_facet Haberland, Annekathrin
Santos, Robson A.S.
Schimke, Ingolf
Wallukat, Gerd
author_sort Haberland, Annekathrin
collection PubMed
description Metabolic syndrome and cardiomyopathies are long-term consequences of chemo- and radiotherapy and develop long after completing the initial tumor treatment. The slow progression of such late effects might be an indication of the involvement of autoimmune processes in the development of such follow-up consequences. Functionally active autoantibodies, which permanently stimulate relevant cell receptors, might be a crucial component. Here, we report the detection of functionally active agonistic autoantibodies such as the autoantibody against the adrenergic alpha1-receptor, the muscarinic M2-receptor, and the newly discovered autoantibody against the Mas-receptor in the plasma of a cancer survivor following chemotherapy treatment.
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spelling pubmed-36180422013-04-08 Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy? Haberland, Annekathrin Santos, Robson A.S. Schimke, Ingolf Wallukat, Gerd Case Rep Oncol Published online: February, 2013 Metabolic syndrome and cardiomyopathies are long-term consequences of chemo- and radiotherapy and develop long after completing the initial tumor treatment. The slow progression of such late effects might be an indication of the involvement of autoimmune processes in the development of such follow-up consequences. Functionally active autoantibodies, which permanently stimulate relevant cell receptors, might be a crucial component. Here, we report the detection of functionally active agonistic autoantibodies such as the autoantibody against the adrenergic alpha1-receptor, the muscarinic M2-receptor, and the newly discovered autoantibody against the Mas-receptor in the plasma of a cancer survivor following chemotherapy treatment. S. Karger AG 2013-02-21 /pmc/articles/PMC3618042/ /pubmed/23569443 http://dx.doi.org/10.1159/000348425 Text en Copyright © 2013 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: February, 2013
Haberland, Annekathrin
Santos, Robson A.S.
Schimke, Ingolf
Wallukat, Gerd
Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy?
title Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy?
title_full Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy?
title_fullStr Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy?
title_full_unstemmed Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy?
title_short Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy?
title_sort are agonistic autoantibodies against g-protein coupled receptors involved in the development of long-term side effects of tumor chemotherapy?
topic Published online: February, 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618042/
https://www.ncbi.nlm.nih.gov/pubmed/23569443
http://dx.doi.org/10.1159/000348425
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