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Gastrointestinal Stromal Tumor: A Rare Abdominal Tumor
Gastrointestinal stromal tumors (GISTs) are rare abdominal tumors which arise from the interstitial cells of Cajal in the gastrointestinal tract. Gastric GISTs are the most commonly seen GIST tumors and may grow to a very large size. They are often associated with abdominal pain, anorexia and weight...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618098/ https://www.ncbi.nlm.nih.gov/pubmed/23569450 http://dx.doi.org/10.1159/000350061 |
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author | Shaheen, Shagufta Guddati, Achuta K. |
author_facet | Shaheen, Shagufta Guddati, Achuta K. |
author_sort | Shaheen, Shagufta |
collection | PubMed |
description | Gastrointestinal stromal tumors (GISTs) are rare abdominal tumors which arise from the interstitial cells of Cajal in the gastrointestinal tract. Gastric GISTs are the most commonly seen GIST tumors and may grow to a very large size. They are often associated with abdominal pain, anorexia and weight loss. Most of them can be detected by CT. These tumors have been found to harbor mutations in CD117 which causes constitutional activation of the tyrosine kinase signaling pathway and is considered to be pathognomic. Tyrosine kinase inhibitors such as imatinib have revolutionized the treatment of these tumors, which are otherwise resistant to conventional chemotherapy and radiotherapy. Although surgical resection is the mainstay of treatment, tyrosine kinase inhibitors have been useful in prolonging the recurrence-free survival of these patients. Resistance to imatinib has been reported in GISTs with specific mutations. We present a case of gastric GIST which grew to a very large size and was associated with abdominal pain and weight loss. It was successfully resected and the patient was commenced on imatinib therapy. |
format | Online Article Text |
id | pubmed-3618098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-36180982013-04-08 Gastrointestinal Stromal Tumor: A Rare Abdominal Tumor Shaheen, Shagufta Guddati, Achuta K. Case Rep Oncol Published online: March, 2013 Gastrointestinal stromal tumors (GISTs) are rare abdominal tumors which arise from the interstitial cells of Cajal in the gastrointestinal tract. Gastric GISTs are the most commonly seen GIST tumors and may grow to a very large size. They are often associated with abdominal pain, anorexia and weight loss. Most of them can be detected by CT. These tumors have been found to harbor mutations in CD117 which causes constitutional activation of the tyrosine kinase signaling pathway and is considered to be pathognomic. Tyrosine kinase inhibitors such as imatinib have revolutionized the treatment of these tumors, which are otherwise resistant to conventional chemotherapy and radiotherapy. Although surgical resection is the mainstay of treatment, tyrosine kinase inhibitors have been useful in prolonging the recurrence-free survival of these patients. Resistance to imatinib has been reported in GISTs with specific mutations. We present a case of gastric GIST which grew to a very large size and was associated with abdominal pain and weight loss. It was successfully resected and the patient was commenced on imatinib therapy. S. Karger AG 2013-03-20 /pmc/articles/PMC3618098/ /pubmed/23569450 http://dx.doi.org/10.1159/000350061 Text en Copyright © 2013 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published online: March, 2013 Shaheen, Shagufta Guddati, Achuta K. Gastrointestinal Stromal Tumor: A Rare Abdominal Tumor |
title | Gastrointestinal Stromal Tumor: A Rare Abdominal Tumor |
title_full | Gastrointestinal Stromal Tumor: A Rare Abdominal Tumor |
title_fullStr | Gastrointestinal Stromal Tumor: A Rare Abdominal Tumor |
title_full_unstemmed | Gastrointestinal Stromal Tumor: A Rare Abdominal Tumor |
title_short | Gastrointestinal Stromal Tumor: A Rare Abdominal Tumor |
title_sort | gastrointestinal stromal tumor: a rare abdominal tumor |
topic | Published online: March, 2013 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618098/ https://www.ncbi.nlm.nih.gov/pubmed/23569450 http://dx.doi.org/10.1159/000350061 |
work_keys_str_mv | AT shaheenshagufta gastrointestinalstromaltumorarareabdominaltumor AT guddatiachutak gastrointestinalstromaltumorarareabdominaltumor |