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Mechanisms of Topoisomerase I (TOP1) Gene Copy Number Increase in a Stage III Colorectal Cancer Patient Cohort

BACKGROUND: Topoisomerase I (Top1) is the target of Top1 inhibitor chemotherapy. The TOP1 gene, located at 20q12-q13.1, is frequently detected at elevated copy numbers in colorectal cancer (CRC). The present study explores the mechanism, frequency and prognostic impact of TOP1 gene aberrations in st...

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Detalles Bibliográficos
Autores principales:	Smith, David Hersi, Christensen, Ib Jarle, Jensen, Niels Frank, Markussen, Bo, Rømer, Maria Unni, Nygård, Sune Boris, Müller, Sven, Nielsen, Hans Jørgen, Brünner, Nils, Nielsen, Kirsten Vang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618421/ https://www.ncbi.nlm.nih.gov/pubmed/23577133 http://dx.doi.org/10.1371/journal.pone.0060613

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