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Sex Bias in Experimental Immune-Mediated, Drug-Induced Liver Injury in BALB/c Mice: Suggested Roles for Tregs, Estrogen, and IL-6

BACKGROUND AND AIMS: Immune-mediated, drug-induced liver injury (DILI) triggered by drug haptens is more prevalent in women than in men. However, mechanisms responsible for this sex bias are not clear. Immune regulation by CD4+CD25+FoxP3+ regulatory T-cells (Tregs) and 17β-estradiol is crucial in th...

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Detalles Bibliográficos
Autores principales:	Cho, Joonhee, Kim, Lina, Li, Zhaoxia, Rose, Noel R., Talor, Monica Vladut, Njoku, Dolores B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618451/ https://www.ncbi.nlm.nih.gov/pubmed/23577207 http://dx.doi.org/10.1371/journal.pone.0061186

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