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SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

The inhibitory protein SOCS3 plays a key role in the immune and hematopoietic systems by regulating signaling induced by specific cytokines. SOCS3 functions by inhibiting the catalytic activity of Janus Kinases (JAKs) that initiate signaling within the cell. We determined the crystal structure of a...

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Detalles Bibliográficos
Autores principales:	Kershaw, Nadia J., Murphy, James M., Liau, Nicholas P.D., Varghese, Leila N., Laktyushin, Artem, Whitlock, Eden L., Lucet, Isabelle S., Nicola, Nicos A., Babon, Jeffrey J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618588/ https://www.ncbi.nlm.nih.gov/pubmed/23454976 http://dx.doi.org/10.1038/nsmb.2519

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