Cargando…

Selective Intermittent Preventive Treatment of Vivax Malaria: Reduction of Malaria Incidence in an Open Cohort Study in Brazilian Amazon

In children, the Intermittent Preventive Treatment (IPTc), currently called Seasonal Malaria Chemoprevention (SMC), was considered effective on malaria control due to the reduction of its incidence in Papua New Guinea and in some areas with seasonal malaria in Africa. However, the IPT has not been i...

Descripción completa

Detalles Bibliográficos
Autores principales: Katsuragawa, Tony Hiroshi, Gil, Luiz Herman Soares, de Lima, Alzemar Alves, Freitag, Elci Marlei, dos Santos, Tatiana Marcondes, do Nascimento Filha, Maria Teixeira, dos Santos Júnior, Alcides Procópio Justiniano, da Silva, Josiane Mendes, Rodrigues, Aline de Freitas, Tada, Mauro Shugiro, Fontes, Cor Jesus Fernandes, Pereira da Silva, Luiz Hildebrando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618938/
https://www.ncbi.nlm.nih.gov/pubmed/23577276
http://dx.doi.org/10.1155/2013/310246
Descripción
Sumario:In children, the Intermittent Preventive Treatment (IPTc), currently called Seasonal Malaria Chemoprevention (SMC), was considered effective on malaria control due to the reduction of its incidence in Papua New Guinea and in some areas with seasonal malaria in Africa. However, the IPT has not been indicated because of its association with drug resistance and for hindering natural immunity development. Thus, we evaluated the alternative IPT impact on malaria incidence in three riverside communities on Madeira River, in the municipality of Porto Velho, RO. We denominate this scheme Selective Intermittent Preventive Treatment (SIPT). The SIPT consists in a weekly dose of two 150 mg chloroquine tablets for 12 weeks, for adults, and an equivalent dose for children, after complete supervised treatment for P. vivax infection. This scheme is recommend by Brazilian Health Ministry to avoid frequent relapses. The clinic parasitological and epidemiological surveillance showed a significant reduction on vivax malaria incidence. The results showed a reduction on relapses and recurrence of malaria after SIPT implementation. The SIPT can be effective on vivax malaria control in localities with high transmission risk in the Brazilian Amazon.