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Selective Intermittent Preventive Treatment of Vivax Malaria: Reduction of Malaria Incidence in an Open Cohort Study in Brazilian Amazon

In children, the Intermittent Preventive Treatment (IPTc), currently called Seasonal Malaria Chemoprevention (SMC), was considered effective on malaria control due to the reduction of its incidence in Papua New Guinea and in some areas with seasonal malaria in Africa. However, the IPT has not been i...

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Autores principales: Katsuragawa, Tony Hiroshi, Gil, Luiz Herman Soares, de Lima, Alzemar Alves, Freitag, Elci Marlei, dos Santos, Tatiana Marcondes, do Nascimento Filha, Maria Teixeira, dos Santos Júnior, Alcides Procópio Justiniano, da Silva, Josiane Mendes, Rodrigues, Aline de Freitas, Tada, Mauro Shugiro, Fontes, Cor Jesus Fernandes, Pereira da Silva, Luiz Hildebrando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618938/
https://www.ncbi.nlm.nih.gov/pubmed/23577276
http://dx.doi.org/10.1155/2013/310246
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author Katsuragawa, Tony Hiroshi
Gil, Luiz Herman Soares
de Lima, Alzemar Alves
Freitag, Elci Marlei
dos Santos, Tatiana Marcondes
do Nascimento Filha, Maria Teixeira
dos Santos Júnior, Alcides Procópio Justiniano
da Silva, Josiane Mendes
Rodrigues, Aline de Freitas
Tada, Mauro Shugiro
Fontes, Cor Jesus Fernandes
Pereira da Silva, Luiz Hildebrando
author_facet Katsuragawa, Tony Hiroshi
Gil, Luiz Herman Soares
de Lima, Alzemar Alves
Freitag, Elci Marlei
dos Santos, Tatiana Marcondes
do Nascimento Filha, Maria Teixeira
dos Santos Júnior, Alcides Procópio Justiniano
da Silva, Josiane Mendes
Rodrigues, Aline de Freitas
Tada, Mauro Shugiro
Fontes, Cor Jesus Fernandes
Pereira da Silva, Luiz Hildebrando
author_sort Katsuragawa, Tony Hiroshi
collection PubMed
description In children, the Intermittent Preventive Treatment (IPTc), currently called Seasonal Malaria Chemoprevention (SMC), was considered effective on malaria control due to the reduction of its incidence in Papua New Guinea and in some areas with seasonal malaria in Africa. However, the IPT has not been indicated because of its association with drug resistance and for hindering natural immunity development. Thus, we evaluated the alternative IPT impact on malaria incidence in three riverside communities on Madeira River, in the municipality of Porto Velho, RO. We denominate this scheme Selective Intermittent Preventive Treatment (SIPT). The SIPT consists in a weekly dose of two 150 mg chloroquine tablets for 12 weeks, for adults, and an equivalent dose for children, after complete supervised treatment for P. vivax infection. This scheme is recommend by Brazilian Health Ministry to avoid frequent relapses. The clinic parasitological and epidemiological surveillance showed a significant reduction on vivax malaria incidence. The results showed a reduction on relapses and recurrence of malaria after SIPT implementation. The SIPT can be effective on vivax malaria control in localities with high transmission risk in the Brazilian Amazon.
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spelling pubmed-36189382013-04-10 Selective Intermittent Preventive Treatment of Vivax Malaria: Reduction of Malaria Incidence in an Open Cohort Study in Brazilian Amazon Katsuragawa, Tony Hiroshi Gil, Luiz Herman Soares de Lima, Alzemar Alves Freitag, Elci Marlei dos Santos, Tatiana Marcondes do Nascimento Filha, Maria Teixeira dos Santos Júnior, Alcides Procópio Justiniano da Silva, Josiane Mendes Rodrigues, Aline de Freitas Tada, Mauro Shugiro Fontes, Cor Jesus Fernandes Pereira da Silva, Luiz Hildebrando Malar Res Treat Research Article In children, the Intermittent Preventive Treatment (IPTc), currently called Seasonal Malaria Chemoprevention (SMC), was considered effective on malaria control due to the reduction of its incidence in Papua New Guinea and in some areas with seasonal malaria in Africa. However, the IPT has not been indicated because of its association with drug resistance and for hindering natural immunity development. Thus, we evaluated the alternative IPT impact on malaria incidence in three riverside communities on Madeira River, in the municipality of Porto Velho, RO. We denominate this scheme Selective Intermittent Preventive Treatment (SIPT). The SIPT consists in a weekly dose of two 150 mg chloroquine tablets for 12 weeks, for adults, and an equivalent dose for children, after complete supervised treatment for P. vivax infection. This scheme is recommend by Brazilian Health Ministry to avoid frequent relapses. The clinic parasitological and epidemiological surveillance showed a significant reduction on vivax malaria incidence. The results showed a reduction on relapses and recurrence of malaria after SIPT implementation. The SIPT can be effective on vivax malaria control in localities with high transmission risk in the Brazilian Amazon. Hindawi Publishing Corporation 2013 2013-03-21 /pmc/articles/PMC3618938/ /pubmed/23577276 http://dx.doi.org/10.1155/2013/310246 Text en Copyright © 2013 Tony Hiroshi Katsuragawa et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Katsuragawa, Tony Hiroshi
Gil, Luiz Herman Soares
de Lima, Alzemar Alves
Freitag, Elci Marlei
dos Santos, Tatiana Marcondes
do Nascimento Filha, Maria Teixeira
dos Santos Júnior, Alcides Procópio Justiniano
da Silva, Josiane Mendes
Rodrigues, Aline de Freitas
Tada, Mauro Shugiro
Fontes, Cor Jesus Fernandes
Pereira da Silva, Luiz Hildebrando
Selective Intermittent Preventive Treatment of Vivax Malaria: Reduction of Malaria Incidence in an Open Cohort Study in Brazilian Amazon
title Selective Intermittent Preventive Treatment of Vivax Malaria: Reduction of Malaria Incidence in an Open Cohort Study in Brazilian Amazon
title_full Selective Intermittent Preventive Treatment of Vivax Malaria: Reduction of Malaria Incidence in an Open Cohort Study in Brazilian Amazon
title_fullStr Selective Intermittent Preventive Treatment of Vivax Malaria: Reduction of Malaria Incidence in an Open Cohort Study in Brazilian Amazon
title_full_unstemmed Selective Intermittent Preventive Treatment of Vivax Malaria: Reduction of Malaria Incidence in an Open Cohort Study in Brazilian Amazon
title_short Selective Intermittent Preventive Treatment of Vivax Malaria: Reduction of Malaria Incidence in an Open Cohort Study in Brazilian Amazon
title_sort selective intermittent preventive treatment of vivax malaria: reduction of malaria incidence in an open cohort study in brazilian amazon
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618938/
https://www.ncbi.nlm.nih.gov/pubmed/23577276
http://dx.doi.org/10.1155/2013/310246
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