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Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models

Signal transducer and activator of transcription 3 (Stat3) is a cytoplasmic protein that is activated in response to cytokines and growth factors and acts as a transcription factor. Stat3 plays critical roles in various biological activities including cell proliferation, migration, and survival. Stu...

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Detalles Bibliográficos
Autores principales: Macias, Everardo, Rao, Dharanija, DiGiovanni, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618941/
https://www.ncbi.nlm.nih.gov/pubmed/23577258
http://dx.doi.org/10.1155/2013/684050
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author Macias, Everardo
Rao, Dharanija
DiGiovanni, John
author_facet Macias, Everardo
Rao, Dharanija
DiGiovanni, John
author_sort Macias, Everardo
collection PubMed
description Signal transducer and activator of transcription 3 (Stat3) is a cytoplasmic protein that is activated in response to cytokines and growth factors and acts as a transcription factor. Stat3 plays critical roles in various biological activities including cell proliferation, migration, and survival. Studies using keratinocyte-specific Stat3-deficient mice have revealed that Stat3 plays an important role in skin homeostasis including keratinocyte migration, wound healing, and hair follicle growth. Use of both constitutive and inducible keratinocyte-specific Stat3-deficient mouse models has demonstrated that Stat3 is required for both the initiation and promotion stages of multistage skin carcinogenesis. Further studies using a transgenic mouse model with a gain of function mutant of Stat3 (Stat3C) expressed in the basal layer of the epidermis revealed a novel role for Stat3 in skin tumor progression. Studies using similar Stat3-deficient and gain-of-function mouse models have indicated its similar roles in ultraviolet B (UVB) radiation-mediated skin carcinogenesis. This paper summarizes the use of these various mouse models for studying the role and underlying mechanisms for the function of Stat3 in skin carcinogenesis. Given its significant role throughout the skin carcinogenesis process, Stat3 is an attractive target for skin cancer prevention and treatment.
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spelling pubmed-36189412013-04-10 Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models Macias, Everardo Rao, Dharanija DiGiovanni, John J Skin Cancer Review Article Signal transducer and activator of transcription 3 (Stat3) is a cytoplasmic protein that is activated in response to cytokines and growth factors and acts as a transcription factor. Stat3 plays critical roles in various biological activities including cell proliferation, migration, and survival. Studies using keratinocyte-specific Stat3-deficient mice have revealed that Stat3 plays an important role in skin homeostasis including keratinocyte migration, wound healing, and hair follicle growth. Use of both constitutive and inducible keratinocyte-specific Stat3-deficient mouse models has demonstrated that Stat3 is required for both the initiation and promotion stages of multistage skin carcinogenesis. Further studies using a transgenic mouse model with a gain of function mutant of Stat3 (Stat3C) expressed in the basal layer of the epidermis revealed a novel role for Stat3 in skin tumor progression. Studies using similar Stat3-deficient and gain-of-function mouse models have indicated its similar roles in ultraviolet B (UVB) radiation-mediated skin carcinogenesis. This paper summarizes the use of these various mouse models for studying the role and underlying mechanisms for the function of Stat3 in skin carcinogenesis. Given its significant role throughout the skin carcinogenesis process, Stat3 is an attractive target for skin cancer prevention and treatment. Hindawi Publishing Corporation 2013 2013-03-21 /pmc/articles/PMC3618941/ /pubmed/23577258 http://dx.doi.org/10.1155/2013/684050 Text en Copyright © 2013 Everardo Macias et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Macias, Everardo
Rao, Dharanija
DiGiovanni, John
Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models
title Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models
title_full Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models
title_fullStr Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models
title_full_unstemmed Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models
title_short Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models
title_sort role of stat3 in skin carcinogenesis: insights gained from relevant mouse models
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618941/
https://www.ncbi.nlm.nih.gov/pubmed/23577258
http://dx.doi.org/10.1155/2013/684050
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