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Role of adaptive radiation therapy for pediatric patients with diffuse pontine glioma

We investigate the role of adaptive radiation therapy in pediatric patients with diffuse pontine glioma and the impact of steroid‐related weight gain on treatment parameters utilizing cone‐beam CT. Fifteen patients with diffuse pontine glioma were treated with three‐dimensional conformal radiation t...

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Autores principales: Beltran, Chris, Sharma, Saumya, Merchant, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619395/
https://www.ncbi.nlm.nih.gov/pubmed/21587190
http://dx.doi.org/10.1120/jacmp.v12i2.3421
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author Beltran, Chris
Sharma, Saumya
Merchant, Thomas E.
author_facet Beltran, Chris
Sharma, Saumya
Merchant, Thomas E.
author_sort Beltran, Chris
collection PubMed
description We investigate the role of adaptive radiation therapy in pediatric patients with diffuse pontine glioma and the impact of steroid‐related weight gain on treatment parameters utilizing cone‐beam CT. Fifteen patients with diffuse pontine glioma were treated with three‐dimensional conformal radiation therapy and enrolled on a daily localization protocol. The median age was 6 years (range: 2–13 years). Patient charts were examined to obtain the prescribed daily dose of dexamethasone and weight. The original treatment plan was recalculated based on the data obtained from the daily cone‐beam CT. The changes in target and critical structure doses were calculated using gEUD. Correlations between prescribed dexamethasone, weight gain, source‐to‐skin distance (SSD) changes and dosimetric changes were investigated. Eleven of the 15 patients gained weight during radiation therapy, with an average gain of 2.2 kg (8.0%). The mean gEUD decreased was 0.57 Gy (range: 0.24–1.4 Gy) for the PTV, and the mean gEUD increase for critical structures was 1.14%. No strong correlations between prescribed dexamethasone doses, weight gain and dosimetric changes were found. Change in SSD vs. dose to PTV was correlated [Formula: see text]. Weight gain and changes to the external surface are apparent in these patients; however, the dosimetric changes to the target and critical structures were small and in most cases did not warrant an adaptive plan. The potential exists for a decrease in target dose in these patients; therefore, they should be monitored to assess for replanning when necessary. PACS number: 87.53Jw
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spelling pubmed-36193952018-04-02 Role of adaptive radiation therapy for pediatric patients with diffuse pontine glioma Beltran, Chris Sharma, Saumya Merchant, Thomas E. J Appl Clin Med Phys Radiation Oncology Physics We investigate the role of adaptive radiation therapy in pediatric patients with diffuse pontine glioma and the impact of steroid‐related weight gain on treatment parameters utilizing cone‐beam CT. Fifteen patients with diffuse pontine glioma were treated with three‐dimensional conformal radiation therapy and enrolled on a daily localization protocol. The median age was 6 years (range: 2–13 years). Patient charts were examined to obtain the prescribed daily dose of dexamethasone and weight. The original treatment plan was recalculated based on the data obtained from the daily cone‐beam CT. The changes in target and critical structure doses were calculated using gEUD. Correlations between prescribed dexamethasone, weight gain, source‐to‐skin distance (SSD) changes and dosimetric changes were investigated. Eleven of the 15 patients gained weight during radiation therapy, with an average gain of 2.2 kg (8.0%). The mean gEUD decreased was 0.57 Gy (range: 0.24–1.4 Gy) for the PTV, and the mean gEUD increase for critical structures was 1.14%. No strong correlations between prescribed dexamethasone doses, weight gain and dosimetric changes were found. Change in SSD vs. dose to PTV was correlated [Formula: see text]. Weight gain and changes to the external surface are apparent in these patients; however, the dosimetric changes to the target and critical structures were small and in most cases did not warrant an adaptive plan. The potential exists for a decrease in target dose in these patients; therefore, they should be monitored to assess for replanning when necessary. PACS number: 87.53Jw John Wiley and Sons Inc. 2011-01-30 /pmc/articles/PMC3619395/ /pubmed/21587190 http://dx.doi.org/10.1120/jacmp.v12i2.3421 Text en © 2011 The Authors. https://creativecommons.org/licenses/by/3.0/This is an open access article under the terms of the Creative Commons Attribution (https://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Beltran, Chris
Sharma, Saumya
Merchant, Thomas E.
Role of adaptive radiation therapy for pediatric patients with diffuse pontine glioma
title Role of adaptive radiation therapy for pediatric patients with diffuse pontine glioma
title_full Role of adaptive radiation therapy for pediatric patients with diffuse pontine glioma
title_fullStr Role of adaptive radiation therapy for pediatric patients with diffuse pontine glioma
title_full_unstemmed Role of adaptive radiation therapy for pediatric patients with diffuse pontine glioma
title_short Role of adaptive radiation therapy for pediatric patients with diffuse pontine glioma
title_sort role of adaptive radiation therapy for pediatric patients with diffuse pontine glioma
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619395/
https://www.ncbi.nlm.nih.gov/pubmed/21587190
http://dx.doi.org/10.1120/jacmp.v12i2.3421
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