Cargando…
Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment
Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels. Therefore, the aim of this study was to verify if IFNG, IL12B, TNF, IL17A, IL10, and TGFB1 gene polymorphisms influence the immune response of Brazi...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619634/ https://www.ncbi.nlm.nih.gov/pubmed/23634300 http://dx.doi.org/10.1155/2013/285094 |
_version_ | 1782265499388739584 |
---|---|
author | Peresi, Eliana Oliveira, Larissa Ragozo Cardoso da Silva, Weber Laurentino da Costa, Érika Alessandra Pellison Nunes Araujo, João Pessoa Ayres, Jairo Aparecido Fortes, Maria Rita Parise Graviss, Edward A. Pereira, Ana Carla Calvi, Sueli Aparecida |
author_facet | Peresi, Eliana Oliveira, Larissa Ragozo Cardoso da Silva, Weber Laurentino da Costa, Érika Alessandra Pellison Nunes Araujo, João Pessoa Ayres, Jairo Aparecido Fortes, Maria Rita Parise Graviss, Edward A. Pereira, Ana Carla Calvi, Sueli Aparecida |
author_sort | Peresi, Eliana |
collection | PubMed |
description | Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels. Therefore, the aim of this study was to verify if IFNG, IL12B, TNF, IL17A, IL10, and TGFB1 gene polymorphisms influence the immune response of Brazilian patients with pulmonary tuberculosis (PTB) at different time points of antituberculosis treatment (T1, T2, and T3). Our results showed the following associations: IFNG +874 T allele and IFNG +2109 A allele with higher IFN-γ levels; IL12B +1188 C allele with higher IL-12 levels; TNF −308 A allele with higher TNF-α plasma levels in controls and mRNA levels in PTB patients at T1; IL17A A allele at rs7747909 with higher IL-17 levels; IL10 −819 T allele with higher IL-10 levels; and TGFB1 +29 CC genotype higher TGF-β plasma levels in PTB patients at T2. The present study suggests that IFNG +874T/A, IFNG +2109A/G, IL12B +1188A/C, IL10 −819C/T, and TGFB1 +21C/T are associated with differential cytokine levels in pulmonary tuberculosis patients and may play a role in the initiation and maintenance of acquired cellular immunity to tuberculosis and in the outcome of the active disease while on antituberculosis treatment. |
format | Online Article Text |
id | pubmed-3619634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36196342013-04-30 Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment Peresi, Eliana Oliveira, Larissa Ragozo Cardoso da Silva, Weber Laurentino da Costa, Érika Alessandra Pellison Nunes Araujo, João Pessoa Ayres, Jairo Aparecido Fortes, Maria Rita Parise Graviss, Edward A. Pereira, Ana Carla Calvi, Sueli Aparecida Tuberc Res Treat Clinical Study Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels. Therefore, the aim of this study was to verify if IFNG, IL12B, TNF, IL17A, IL10, and TGFB1 gene polymorphisms influence the immune response of Brazilian patients with pulmonary tuberculosis (PTB) at different time points of antituberculosis treatment (T1, T2, and T3). Our results showed the following associations: IFNG +874 T allele and IFNG +2109 A allele with higher IFN-γ levels; IL12B +1188 C allele with higher IL-12 levels; TNF −308 A allele with higher TNF-α plasma levels in controls and mRNA levels in PTB patients at T1; IL17A A allele at rs7747909 with higher IL-17 levels; IL10 −819 T allele with higher IL-10 levels; and TGFB1 +29 CC genotype higher TGF-β plasma levels in PTB patients at T2. The present study suggests that IFNG +874T/A, IFNG +2109A/G, IL12B +1188A/C, IL10 −819C/T, and TGFB1 +21C/T are associated with differential cytokine levels in pulmonary tuberculosis patients and may play a role in the initiation and maintenance of acquired cellular immunity to tuberculosis and in the outcome of the active disease while on antituberculosis treatment. Hindawi Publishing Corporation 2013 2013-03-27 /pmc/articles/PMC3619634/ /pubmed/23634300 http://dx.doi.org/10.1155/2013/285094 Text en Copyright © 2013 Eliana Peresi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Peresi, Eliana Oliveira, Larissa Ragozo Cardoso da Silva, Weber Laurentino da Costa, Érika Alessandra Pellison Nunes Araujo, João Pessoa Ayres, Jairo Aparecido Fortes, Maria Rita Parise Graviss, Edward A. Pereira, Ana Carla Calvi, Sueli Aparecida Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment |
title | Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment |
title_full | Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment |
title_fullStr | Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment |
title_full_unstemmed | Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment |
title_short | Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment |
title_sort | cytokine polymorphisms, their influence and levels in brazilian patients with pulmonary tuberculosis during antituberculosis treatment |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619634/ https://www.ncbi.nlm.nih.gov/pubmed/23634300 http://dx.doi.org/10.1155/2013/285094 |
work_keys_str_mv | AT peresieliana cytokinepolymorphismstheirinfluenceandlevelsinbrazilianpatientswithpulmonarytuberculosisduringantituberculosistreatment AT oliveiralarissaragozocardoso cytokinepolymorphismstheirinfluenceandlevelsinbrazilianpatientswithpulmonarytuberculosisduringantituberculosistreatment AT dasilvaweberlaurentino cytokinepolymorphismstheirinfluenceandlevelsinbrazilianpatientswithpulmonarytuberculosisduringantituberculosistreatment AT dacostaerikaalessandrapellisonnunes cytokinepolymorphismstheirinfluenceandlevelsinbrazilianpatientswithpulmonarytuberculosisduringantituberculosistreatment AT araujojoaopessoa cytokinepolymorphismstheirinfluenceandlevelsinbrazilianpatientswithpulmonarytuberculosisduringantituberculosistreatment AT ayresjairoaparecido cytokinepolymorphismstheirinfluenceandlevelsinbrazilianpatientswithpulmonarytuberculosisduringantituberculosistreatment AT fortesmariaritaparise cytokinepolymorphismstheirinfluenceandlevelsinbrazilianpatientswithpulmonarytuberculosisduringantituberculosistreatment AT gravissedwarda cytokinepolymorphismstheirinfluenceandlevelsinbrazilianpatientswithpulmonarytuberculosisduringantituberculosistreatment AT pereiraanacarla cytokinepolymorphismstheirinfluenceandlevelsinbrazilianpatientswithpulmonarytuberculosisduringantituberculosistreatment AT calvisueliaparecida cytokinepolymorphismstheirinfluenceandlevelsinbrazilianpatientswithpulmonarytuberculosisduringantituberculosistreatment |