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Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment

Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels. Therefore, the aim of this study was to verify if IFNG, IL12B, TNF, IL17A, IL10, and TGFB1 gene polymorphisms influence the immune response of Brazi...

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Autores principales: Peresi, Eliana, Oliveira, Larissa Ragozo Cardoso, da Silva, Weber Laurentino, da Costa, Érika Alessandra Pellison Nunes, Araujo, João Pessoa, Ayres, Jairo Aparecido, Fortes, Maria Rita Parise, Graviss, Edward A., Pereira, Ana Carla, Calvi, Sueli Aparecida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619634/
https://www.ncbi.nlm.nih.gov/pubmed/23634300
http://dx.doi.org/10.1155/2013/285094
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author Peresi, Eliana
Oliveira, Larissa Ragozo Cardoso
da Silva, Weber Laurentino
da Costa, Érika Alessandra Pellison Nunes
Araujo, João Pessoa
Ayres, Jairo Aparecido
Fortes, Maria Rita Parise
Graviss, Edward A.
Pereira, Ana Carla
Calvi, Sueli Aparecida
author_facet Peresi, Eliana
Oliveira, Larissa Ragozo Cardoso
da Silva, Weber Laurentino
da Costa, Érika Alessandra Pellison Nunes
Araujo, João Pessoa
Ayres, Jairo Aparecido
Fortes, Maria Rita Parise
Graviss, Edward A.
Pereira, Ana Carla
Calvi, Sueli Aparecida
author_sort Peresi, Eliana
collection PubMed
description Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels. Therefore, the aim of this study was to verify if IFNG, IL12B, TNF, IL17A, IL10, and TGFB1 gene polymorphisms influence the immune response of Brazilian patients with pulmonary tuberculosis (PTB) at different time points of antituberculosis treatment (T1, T2, and T3). Our results showed the following associations: IFNG +874 T allele and IFNG +2109 A allele with higher IFN-γ levels; IL12B +1188 C allele with higher IL-12 levels; TNF −308 A allele with higher TNF-α plasma levels in controls and mRNA levels in PTB patients at T1; IL17A A allele at rs7747909 with higher IL-17 levels; IL10 −819 T allele with higher IL-10 levels; and TGFB1 +29 CC genotype higher TGF-β plasma levels in PTB patients at T2. The present study suggests that IFNG +874T/A, IFNG +2109A/G, IL12B +1188A/C, IL10 −819C/T, and TGFB1 +21C/T are associated with differential cytokine levels in pulmonary tuberculosis patients and may play a role in the initiation and maintenance of acquired cellular immunity to tuberculosis and in the outcome of the active disease while on antituberculosis treatment.
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spelling pubmed-36196342013-04-30 Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment Peresi, Eliana Oliveira, Larissa Ragozo Cardoso da Silva, Weber Laurentino da Costa, Érika Alessandra Pellison Nunes Araujo, João Pessoa Ayres, Jairo Aparecido Fortes, Maria Rita Parise Graviss, Edward A. Pereira, Ana Carla Calvi, Sueli Aparecida Tuberc Res Treat Clinical Study Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels. Therefore, the aim of this study was to verify if IFNG, IL12B, TNF, IL17A, IL10, and TGFB1 gene polymorphisms influence the immune response of Brazilian patients with pulmonary tuberculosis (PTB) at different time points of antituberculosis treatment (T1, T2, and T3). Our results showed the following associations: IFNG +874 T allele and IFNG +2109 A allele with higher IFN-γ levels; IL12B +1188 C allele with higher IL-12 levels; TNF −308 A allele with higher TNF-α plasma levels in controls and mRNA levels in PTB patients at T1; IL17A A allele at rs7747909 with higher IL-17 levels; IL10 −819 T allele with higher IL-10 levels; and TGFB1 +29 CC genotype higher TGF-β plasma levels in PTB patients at T2. The present study suggests that IFNG +874T/A, IFNG +2109A/G, IL12B +1188A/C, IL10 −819C/T, and TGFB1 +21C/T are associated with differential cytokine levels in pulmonary tuberculosis patients and may play a role in the initiation and maintenance of acquired cellular immunity to tuberculosis and in the outcome of the active disease while on antituberculosis treatment. Hindawi Publishing Corporation 2013 2013-03-27 /pmc/articles/PMC3619634/ /pubmed/23634300 http://dx.doi.org/10.1155/2013/285094 Text en Copyright © 2013 Eliana Peresi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Peresi, Eliana
Oliveira, Larissa Ragozo Cardoso
da Silva, Weber Laurentino
da Costa, Érika Alessandra Pellison Nunes
Araujo, João Pessoa
Ayres, Jairo Aparecido
Fortes, Maria Rita Parise
Graviss, Edward A.
Pereira, Ana Carla
Calvi, Sueli Aparecida
Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment
title Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment
title_full Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment
title_fullStr Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment
title_full_unstemmed Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment
title_short Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment
title_sort cytokine polymorphisms, their influence and levels in brazilian patients with pulmonary tuberculosis during antituberculosis treatment
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619634/
https://www.ncbi.nlm.nih.gov/pubmed/23634300
http://dx.doi.org/10.1155/2013/285094
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