DNA Vaccine Delivered by a Needle-Free Injection Device Improves Potency of Priming for Antibody and CD8+ T-Cell Responses after rAd5 Boost in a Randomized Clinical Trial

BACKGROUND: DNA vaccine immunogenicity has been limited by inefficient delivery. Needle-free delivery of DNA using a CO(2)-powered Biojector® device was compared to delivery by needle and syringe and evaluated for safety and immunogenicity. METHODS: Forty adults, 18–50 years, were randomly assigned...

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Detalles Bibliográficos
Autores principales: Graham, Barney S., Enama, Mary E., Nason, Martha C., Gordon, Ingelise J., Peel, Sheila A., Ledgerwood, Julie E., Plummer, Sarah A., Mascola, John R., Bailer, Robert T., Roederer, Mario, Koup, Richard A., Nabel, Gary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620125/
https://www.ncbi.nlm.nih.gov/pubmed/23577062
http://dx.doi.org/10.1371/journal.pone.0059340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620125/
https://www.ncbi.nlm.nih.gov/pubmed/23577062
http://dx.doi.org/10.1371/journal.pone.0059340

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