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Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapies

In PML/RARA-driven acute promyelocytic leukemia (APL), retinoic acid (RA) induces leukemia cell differentiation and transiently clears the disease. Molecularly, RA activates PML/RARA-dependent transcription and also initiates its proteasome-mediated degradation. In contrast, arsenic, the other poten...

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Detalles Bibliográficos
Autores principales:	Ablain, Julien, Leiva, Magdalena, Peres, Laurent, Fonsart, Julien, Anthony, Elodie, de Thé, Hugues
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620357/ https://www.ncbi.nlm.nih.gov/pubmed/23509325 http://dx.doi.org/10.1084/jem.20122337

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