Memantine Reverses Social Withdrawal Induced by Ketamine in Rats

The objective of this study was to determine the effect of memantine on schizophrenia-like symptoms in a ketamine-induced social withdrawal model in rats. We examined therapeutic effects of memantine, an NMDA antagonist, and haloperidol, a classic antipsychotic drug, on this behavioral model. Admini...

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Detalles Bibliográficos
Autores principales: Uribe, Ezequiel, Landaeta, José, Wix, Richard, Eblen, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Science 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620454/
https://www.ncbi.nlm.nih.gov/pubmed/23585718
http://dx.doi.org/10.5607/en.2013.22.1.18
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author Uribe, Ezequiel
Landaeta, José
Wix, Richard
Eblen, Antonio
author_facet Uribe, Ezequiel
Landaeta, José
Wix, Richard
Eblen, Antonio
author_sort Uribe, Ezequiel
collection PubMed
description The objective of this study was to determine the effect of memantine on schizophrenia-like symptoms in a ketamine-induced social withdrawal model in rats. We examined therapeutic effects of memantine, an NMDA antagonist, and haloperidol, a classic antipsychotic drug, on this behavioral model. Administration of memantine (10 or 15 mg·kg(-1)) significantly reduced ketamine-induced social withdrawal, and this effect was more effective than that of haloperidol (0.25 mg·kg(-1)) by restoring the social interaction between rats with no modification in general motor activity. These results suggest that memantine could have a therapeutic potential for schizophrenia.
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spelling pubmed-36204542013-04-12 Memantine Reverses Social Withdrawal Induced by Ketamine in Rats Uribe, Ezequiel Landaeta, José Wix, Richard Eblen, Antonio Exp Neurobiol Original Article The objective of this study was to determine the effect of memantine on schizophrenia-like symptoms in a ketamine-induced social withdrawal model in rats. We examined therapeutic effects of memantine, an NMDA antagonist, and haloperidol, a classic antipsychotic drug, on this behavioral model. Administration of memantine (10 or 15 mg·kg(-1)) significantly reduced ketamine-induced social withdrawal, and this effect was more effective than that of haloperidol (0.25 mg·kg(-1)) by restoring the social interaction between rats with no modification in general motor activity. These results suggest that memantine could have a therapeutic potential for schizophrenia. The Korean Society for Brain and Neural Science 2013-03 2013-03-31 /pmc/articles/PMC3620454/ /pubmed/23585718 http://dx.doi.org/10.5607/en.2013.22.1.18 Text en Copyright © Experimental Neurobiology 2013. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Uribe, Ezequiel
Landaeta, José
Wix, Richard
Eblen, Antonio
Memantine Reverses Social Withdrawal Induced by Ketamine in Rats
title Memantine Reverses Social Withdrawal Induced by Ketamine in Rats
title_full Memantine Reverses Social Withdrawal Induced by Ketamine in Rats
title_fullStr Memantine Reverses Social Withdrawal Induced by Ketamine in Rats
title_full_unstemmed Memantine Reverses Social Withdrawal Induced by Ketamine in Rats
title_short Memantine Reverses Social Withdrawal Induced by Ketamine in Rats
title_sort memantine reverses social withdrawal induced by ketamine in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620454/
https://www.ncbi.nlm.nih.gov/pubmed/23585718
http://dx.doi.org/10.5607/en.2013.22.1.18
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