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Neural Processing of Facial Identity and Emotion in Infants at High-Risk for Autism Spectrum Disorders

Deficits in face processing and social impairment are core characteristics of autism spectrum disorder. The present work examined 7-month-old infants at high-risk for developing autism and typically developing controls at low-risk, using a face perception task designed to differentiate between the e...

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Autores principales: Fox, Sharon E., Wagner, Jennifer B., Shrock, Christine L., Tager-Flusberg, Helen, Nelson, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620489/
https://www.ncbi.nlm.nih.gov/pubmed/23576966
http://dx.doi.org/10.3389/fnhum.2013.00089
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author Fox, Sharon E.
Wagner, Jennifer B.
Shrock, Christine L.
Tager-Flusberg, Helen
Nelson, Charles A.
author_facet Fox, Sharon E.
Wagner, Jennifer B.
Shrock, Christine L.
Tager-Flusberg, Helen
Nelson, Charles A.
author_sort Fox, Sharon E.
collection PubMed
description Deficits in face processing and social impairment are core characteristics of autism spectrum disorder. The present work examined 7-month-old infants at high-risk for developing autism and typically developing controls at low-risk, using a face perception task designed to differentiate between the effects of face identity and facial emotions on neural response using functional Near-Infrared Spectroscopy. In addition, we employed independent component analysis, as well as a novel method of condition-related component selection and classification to identify group differences in hemodynamic waveforms and response distributions associated with face and emotion processing. The results indicate similarities of waveforms, but differences in the magnitude, spatial distribution, and timing of responses between groups. These early differences in local cortical regions and the hemodynamic response may, in turn, contribute to differences in patterns of functional connectivity.
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spelling pubmed-36204892013-04-10 Neural Processing of Facial Identity and Emotion in Infants at High-Risk for Autism Spectrum Disorders Fox, Sharon E. Wagner, Jennifer B. Shrock, Christine L. Tager-Flusberg, Helen Nelson, Charles A. Front Hum Neurosci Neuroscience Deficits in face processing and social impairment are core characteristics of autism spectrum disorder. The present work examined 7-month-old infants at high-risk for developing autism and typically developing controls at low-risk, using a face perception task designed to differentiate between the effects of face identity and facial emotions on neural response using functional Near-Infrared Spectroscopy. In addition, we employed independent component analysis, as well as a novel method of condition-related component selection and classification to identify group differences in hemodynamic waveforms and response distributions associated with face and emotion processing. The results indicate similarities of waveforms, but differences in the magnitude, spatial distribution, and timing of responses between groups. These early differences in local cortical regions and the hemodynamic response may, in turn, contribute to differences in patterns of functional connectivity. Frontiers Media S.A. 2013-04-09 /pmc/articles/PMC3620489/ /pubmed/23576966 http://dx.doi.org/10.3389/fnhum.2013.00089 Text en Copyright © 2013 Fox, Wagner, Shrock, Tager-Flusberg and Nelson. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
Fox, Sharon E.
Wagner, Jennifer B.
Shrock, Christine L.
Tager-Flusberg, Helen
Nelson, Charles A.
Neural Processing of Facial Identity and Emotion in Infants at High-Risk for Autism Spectrum Disorders
title Neural Processing of Facial Identity and Emotion in Infants at High-Risk for Autism Spectrum Disorders
title_full Neural Processing of Facial Identity and Emotion in Infants at High-Risk for Autism Spectrum Disorders
title_fullStr Neural Processing of Facial Identity and Emotion in Infants at High-Risk for Autism Spectrum Disorders
title_full_unstemmed Neural Processing of Facial Identity and Emotion in Infants at High-Risk for Autism Spectrum Disorders
title_short Neural Processing of Facial Identity and Emotion in Infants at High-Risk for Autism Spectrum Disorders
title_sort neural processing of facial identity and emotion in infants at high-risk for autism spectrum disorders
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620489/
https://www.ncbi.nlm.nih.gov/pubmed/23576966
http://dx.doi.org/10.3389/fnhum.2013.00089
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