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Neural Processing of Facial Identity and Emotion in Infants at High-Risk for Autism Spectrum Disorders
Deficits in face processing and social impairment are core characteristics of autism spectrum disorder. The present work examined 7-month-old infants at high-risk for developing autism and typically developing controls at low-risk, using a face perception task designed to differentiate between the e...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620489/ https://www.ncbi.nlm.nih.gov/pubmed/23576966 http://dx.doi.org/10.3389/fnhum.2013.00089 |
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author | Fox, Sharon E. Wagner, Jennifer B. Shrock, Christine L. Tager-Flusberg, Helen Nelson, Charles A. |
author_facet | Fox, Sharon E. Wagner, Jennifer B. Shrock, Christine L. Tager-Flusberg, Helen Nelson, Charles A. |
author_sort | Fox, Sharon E. |
collection | PubMed |
description | Deficits in face processing and social impairment are core characteristics of autism spectrum disorder. The present work examined 7-month-old infants at high-risk for developing autism and typically developing controls at low-risk, using a face perception task designed to differentiate between the effects of face identity and facial emotions on neural response using functional Near-Infrared Spectroscopy. In addition, we employed independent component analysis, as well as a novel method of condition-related component selection and classification to identify group differences in hemodynamic waveforms and response distributions associated with face and emotion processing. The results indicate similarities of waveforms, but differences in the magnitude, spatial distribution, and timing of responses between groups. These early differences in local cortical regions and the hemodynamic response may, in turn, contribute to differences in patterns of functional connectivity. |
format | Online Article Text |
id | pubmed-3620489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-36204892013-04-10 Neural Processing of Facial Identity and Emotion in Infants at High-Risk for Autism Spectrum Disorders Fox, Sharon E. Wagner, Jennifer B. Shrock, Christine L. Tager-Flusberg, Helen Nelson, Charles A. Front Hum Neurosci Neuroscience Deficits in face processing and social impairment are core characteristics of autism spectrum disorder. The present work examined 7-month-old infants at high-risk for developing autism and typically developing controls at low-risk, using a face perception task designed to differentiate between the effects of face identity and facial emotions on neural response using functional Near-Infrared Spectroscopy. In addition, we employed independent component analysis, as well as a novel method of condition-related component selection and classification to identify group differences in hemodynamic waveforms and response distributions associated with face and emotion processing. The results indicate similarities of waveforms, but differences in the magnitude, spatial distribution, and timing of responses between groups. These early differences in local cortical regions and the hemodynamic response may, in turn, contribute to differences in patterns of functional connectivity. Frontiers Media S.A. 2013-04-09 /pmc/articles/PMC3620489/ /pubmed/23576966 http://dx.doi.org/10.3389/fnhum.2013.00089 Text en Copyright © 2013 Fox, Wagner, Shrock, Tager-Flusberg and Nelson. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Neuroscience Fox, Sharon E. Wagner, Jennifer B. Shrock, Christine L. Tager-Flusberg, Helen Nelson, Charles A. Neural Processing of Facial Identity and Emotion in Infants at High-Risk for Autism Spectrum Disorders |
title | Neural Processing of Facial Identity and Emotion in Infants at High-Risk for Autism Spectrum Disorders |
title_full | Neural Processing of Facial Identity and Emotion in Infants at High-Risk for Autism Spectrum Disorders |
title_fullStr | Neural Processing of Facial Identity and Emotion in Infants at High-Risk for Autism Spectrum Disorders |
title_full_unstemmed | Neural Processing of Facial Identity and Emotion in Infants at High-Risk for Autism Spectrum Disorders |
title_short | Neural Processing of Facial Identity and Emotion in Infants at High-Risk for Autism Spectrum Disorders |
title_sort | neural processing of facial identity and emotion in infants at high-risk for autism spectrum disorders |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620489/ https://www.ncbi.nlm.nih.gov/pubmed/23576966 http://dx.doi.org/10.3389/fnhum.2013.00089 |
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