Cargando…

Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study

INTRODUCTION: Lacunar lesions (LLs) and white matter lesions (WMLs) affect cognition. We assessed whether lesions located in specific white matter tracts were associated with cognitive performance taking into account total lesion burden. METHODS: Within the Second Manifestations of ARTerial disease...

Descripción completa

Detalles Bibliográficos
Autores principales: Biesbroek, J. Matthijs, Kuijf, Hugo J., van der Graaf, Yolanda, Vincken, Koen L., Postma, Albert, Mali, Willem P. T. M., Biessels, Geert J., Geerlings, Mirjam I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620525/
https://www.ncbi.nlm.nih.gov/pubmed/23593238
http://dx.doi.org/10.1371/journal.pone.0060541
_version_ 1782265616529358848
author Biesbroek, J. Matthijs
Kuijf, Hugo J.
van der Graaf, Yolanda
Vincken, Koen L.
Postma, Albert
Mali, Willem P. T. M.
Biessels, Geert J.
Geerlings, Mirjam I.
author_facet Biesbroek, J. Matthijs
Kuijf, Hugo J.
van der Graaf, Yolanda
Vincken, Koen L.
Postma, Albert
Mali, Willem P. T. M.
Biessels, Geert J.
Geerlings, Mirjam I.
author_sort Biesbroek, J. Matthijs
collection PubMed
description INTRODUCTION: Lacunar lesions (LLs) and white matter lesions (WMLs) affect cognition. We assessed whether lesions located in specific white matter tracts were associated with cognitive performance taking into account total lesion burden. METHODS: Within the Second Manifestations of ARTerial disease Magnetic Resonance (SMART-MR) study, cross-sectional analyses were performed on 516 patients with manifest arterial disease. We applied an assumption-free voxel-based lesion-symptom mapping approach to investigate the relation between LL and WML locations on 1.5 Tesla brain MRI and compound scores of executive functioning, memory and processing speed. Secondly, a multivariable linear regression model was used to relate the regional volume of LLs and WMLs within specific white matter tracts to cognitive functioning. RESULTS: Voxel-based lesion-symptom mapping identified several clusters of voxels with a significant correlation between WMLs and executive functioning, mostly located within the superior longitudinal fasciculus and anterior thalamic radiation. In the multivariable linear regression model, a statistically significant association was found between regional LL volume within the superior longitudinal fasciculus and anterior thalamic radiation and executive functioning after adjustment for total LL and WML burden. CONCLUSION: These findings identify the superior longitudinal fasciculus and anterior thalamic radiation as key anatomical structures in executive functioning and emphasize the role of strategically located vascular lesions in vascular cognitive impairment.
format Online
Article
Text
id pubmed-3620525
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-36205252013-04-16 Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study Biesbroek, J. Matthijs Kuijf, Hugo J. van der Graaf, Yolanda Vincken, Koen L. Postma, Albert Mali, Willem P. T. M. Biessels, Geert J. Geerlings, Mirjam I. PLoS One Research Article INTRODUCTION: Lacunar lesions (LLs) and white matter lesions (WMLs) affect cognition. We assessed whether lesions located in specific white matter tracts were associated with cognitive performance taking into account total lesion burden. METHODS: Within the Second Manifestations of ARTerial disease Magnetic Resonance (SMART-MR) study, cross-sectional analyses were performed on 516 patients with manifest arterial disease. We applied an assumption-free voxel-based lesion-symptom mapping approach to investigate the relation between LL and WML locations on 1.5 Tesla brain MRI and compound scores of executive functioning, memory and processing speed. Secondly, a multivariable linear regression model was used to relate the regional volume of LLs and WMLs within specific white matter tracts to cognitive functioning. RESULTS: Voxel-based lesion-symptom mapping identified several clusters of voxels with a significant correlation between WMLs and executive functioning, mostly located within the superior longitudinal fasciculus and anterior thalamic radiation. In the multivariable linear regression model, a statistically significant association was found between regional LL volume within the superior longitudinal fasciculus and anterior thalamic radiation and executive functioning after adjustment for total LL and WML burden. CONCLUSION: These findings identify the superior longitudinal fasciculus and anterior thalamic radiation as key anatomical structures in executive functioning and emphasize the role of strategically located vascular lesions in vascular cognitive impairment. Public Library of Science 2013-04-08 /pmc/articles/PMC3620525/ /pubmed/23593238 http://dx.doi.org/10.1371/journal.pone.0060541 Text en © 2013 Biesbroek et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Biesbroek, J. Matthijs
Kuijf, Hugo J.
van der Graaf, Yolanda
Vincken, Koen L.
Postma, Albert
Mali, Willem P. T. M.
Biessels, Geert J.
Geerlings, Mirjam I.
Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study
title Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study
title_full Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study
title_fullStr Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study
title_full_unstemmed Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study
title_short Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study
title_sort association between subcortical vascular lesion location and cognition: a voxel-based and tract-based lesion-symptom mapping study. the smart-mr study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620525/
https://www.ncbi.nlm.nih.gov/pubmed/23593238
http://dx.doi.org/10.1371/journal.pone.0060541
work_keys_str_mv AT biesbroekjmatthijs associationbetweensubcorticalvascularlesionlocationandcognitionavoxelbasedandtractbasedlesionsymptommappingstudythesmartmrstudy
AT kuijfhugoj associationbetweensubcorticalvascularlesionlocationandcognitionavoxelbasedandtractbasedlesionsymptommappingstudythesmartmrstudy
AT vandergraafyolanda associationbetweensubcorticalvascularlesionlocationandcognitionavoxelbasedandtractbasedlesionsymptommappingstudythesmartmrstudy
AT vinckenkoenl associationbetweensubcorticalvascularlesionlocationandcognitionavoxelbasedandtractbasedlesionsymptommappingstudythesmartmrstudy
AT postmaalbert associationbetweensubcorticalvascularlesionlocationandcognitionavoxelbasedandtractbasedlesionsymptommappingstudythesmartmrstudy
AT maliwillemptm associationbetweensubcorticalvascularlesionlocationandcognitionavoxelbasedandtractbasedlesionsymptommappingstudythesmartmrstudy
AT biesselsgeertj associationbetweensubcorticalvascularlesionlocationandcognitionavoxelbasedandtractbasedlesionsymptommappingstudythesmartmrstudy
AT geerlingsmirjami associationbetweensubcorticalvascularlesionlocationandcognitionavoxelbasedandtractbasedlesionsymptommappingstudythesmartmrstudy
AT associationbetweensubcorticalvascularlesionlocationandcognitionavoxelbasedandtractbasedlesionsymptommappingstudythesmartmrstudy