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Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study
INTRODUCTION: Lacunar lesions (LLs) and white matter lesions (WMLs) affect cognition. We assessed whether lesions located in specific white matter tracts were associated with cognitive performance taking into account total lesion burden. METHODS: Within the Second Manifestations of ARTerial disease...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620525/ https://www.ncbi.nlm.nih.gov/pubmed/23593238 http://dx.doi.org/10.1371/journal.pone.0060541 |
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author | Biesbroek, J. Matthijs Kuijf, Hugo J. van der Graaf, Yolanda Vincken, Koen L. Postma, Albert Mali, Willem P. T. M. Biessels, Geert J. Geerlings, Mirjam I. |
author_facet | Biesbroek, J. Matthijs Kuijf, Hugo J. van der Graaf, Yolanda Vincken, Koen L. Postma, Albert Mali, Willem P. T. M. Biessels, Geert J. Geerlings, Mirjam I. |
author_sort | Biesbroek, J. Matthijs |
collection | PubMed |
description | INTRODUCTION: Lacunar lesions (LLs) and white matter lesions (WMLs) affect cognition. We assessed whether lesions located in specific white matter tracts were associated with cognitive performance taking into account total lesion burden. METHODS: Within the Second Manifestations of ARTerial disease Magnetic Resonance (SMART-MR) study, cross-sectional analyses were performed on 516 patients with manifest arterial disease. We applied an assumption-free voxel-based lesion-symptom mapping approach to investigate the relation between LL and WML locations on 1.5 Tesla brain MRI and compound scores of executive functioning, memory and processing speed. Secondly, a multivariable linear regression model was used to relate the regional volume of LLs and WMLs within specific white matter tracts to cognitive functioning. RESULTS: Voxel-based lesion-symptom mapping identified several clusters of voxels with a significant correlation between WMLs and executive functioning, mostly located within the superior longitudinal fasciculus and anterior thalamic radiation. In the multivariable linear regression model, a statistically significant association was found between regional LL volume within the superior longitudinal fasciculus and anterior thalamic radiation and executive functioning after adjustment for total LL and WML burden. CONCLUSION: These findings identify the superior longitudinal fasciculus and anterior thalamic radiation as key anatomical structures in executive functioning and emphasize the role of strategically located vascular lesions in vascular cognitive impairment. |
format | Online Article Text |
id | pubmed-3620525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36205252013-04-16 Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study Biesbroek, J. Matthijs Kuijf, Hugo J. van der Graaf, Yolanda Vincken, Koen L. Postma, Albert Mali, Willem P. T. M. Biessels, Geert J. Geerlings, Mirjam I. PLoS One Research Article INTRODUCTION: Lacunar lesions (LLs) and white matter lesions (WMLs) affect cognition. We assessed whether lesions located in specific white matter tracts were associated with cognitive performance taking into account total lesion burden. METHODS: Within the Second Manifestations of ARTerial disease Magnetic Resonance (SMART-MR) study, cross-sectional analyses were performed on 516 patients with manifest arterial disease. We applied an assumption-free voxel-based lesion-symptom mapping approach to investigate the relation between LL and WML locations on 1.5 Tesla brain MRI and compound scores of executive functioning, memory and processing speed. Secondly, a multivariable linear regression model was used to relate the regional volume of LLs and WMLs within specific white matter tracts to cognitive functioning. RESULTS: Voxel-based lesion-symptom mapping identified several clusters of voxels with a significant correlation between WMLs and executive functioning, mostly located within the superior longitudinal fasciculus and anterior thalamic radiation. In the multivariable linear regression model, a statistically significant association was found between regional LL volume within the superior longitudinal fasciculus and anterior thalamic radiation and executive functioning after adjustment for total LL and WML burden. CONCLUSION: These findings identify the superior longitudinal fasciculus and anterior thalamic radiation as key anatomical structures in executive functioning and emphasize the role of strategically located vascular lesions in vascular cognitive impairment. Public Library of Science 2013-04-08 /pmc/articles/PMC3620525/ /pubmed/23593238 http://dx.doi.org/10.1371/journal.pone.0060541 Text en © 2013 Biesbroek et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Biesbroek, J. Matthijs Kuijf, Hugo J. van der Graaf, Yolanda Vincken, Koen L. Postma, Albert Mali, Willem P. T. M. Biessels, Geert J. Geerlings, Mirjam I. Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study |
title | Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study |
title_full | Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study |
title_fullStr | Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study |
title_full_unstemmed | Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study |
title_short | Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study |
title_sort | association between subcortical vascular lesion location and cognition: a voxel-based and tract-based lesion-symptom mapping study. the smart-mr study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620525/ https://www.ncbi.nlm.nih.gov/pubmed/23593238 http://dx.doi.org/10.1371/journal.pone.0060541 |
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