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Role of ROCK upregulation in endothelial and smooth muscle vascular functions in diabetic rat aorta

BACKGROUND: The RhoA/ROCK signaling pathway mediates vascular smooth muscle contraction while endogenous NO induces vasodilation through its inhibition. Since myosin light chain phosphatase (MLCP) and eNOS are targeted by RhoA/ROCK upregulation then turn to lead abnormalities in vasculature, we aime...

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Detalles Bibliográficos
Autores principales:	Cicek, Figen Amber, Kandilci, Hilmi B, Turan, Belma
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620917/ https://www.ncbi.nlm.nih.gov/pubmed/23530857 http://dx.doi.org/10.1186/1475-2840-12-51

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