Anti-tumor necrosis factor (V)NAR single domains reduce lethality and regulate underlying inflammatory response in a murine model of endotoxic shock

BACKGROUND: In sepsis, tumor necrosis factor (TNF) is the key factor triggering respiratory burst, tissue injury and disseminated coagulation. Anti-TNF strategies based on monoclonal antibodies or F(ab’)(2) fragments have been used in sepsis with contradictory results. Immunoglobulin new antigen rec...

Descripción completa

Detalles Bibliográficos
Autores principales: Bojalil, Rafael, Mata-González, María Teresa, Sánchez-Muñoz, Fausto, Yee, Yepci, Argueta, Iván, Bolaños, Lucía, Amezcua-Guerra, Luis Manuel, Camacho-Villegas, Tanya Amanda, Sánchez-Castrejón, Edna, García-Ubbelohde, Walter Jakob, Licea-Navarro, Alexei Fedorovish, Márquez-Velasco, Ricardo, Paniagua-Solís, Jorge Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621089/
https://www.ncbi.nlm.nih.gov/pubmed/23548047
http://dx.doi.org/10.1186/1471-2172-14-17

Ejemplares similares

Ejemplares similares