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Dietary Acrylamide Intake during Pregnancy and Fetal Growth—Results from the Norwegian Mother and Child Cohort Study (MoBa)
Background: Acrylamide has shown developmental and reproductive toxicity in animals, as well as neurotoxic effects in humans with occupational exposures. Because it is widespread in food and can pass through the human placenta, concerns have been raised about potential developmental effects of dieta...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Institute of Environmental Health Sciences
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621181/ https://www.ncbi.nlm.nih.gov/pubmed/23204292 http://dx.doi.org/10.1289/ehp.1205396 |
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author | Duarte-Salles, Talita von Stedingk, Hans Granum, Berit Gützkow, Kristine B. Rydberg, Per Törnqvist, Margareta Mendez, Michelle A. Brunborg, Gunnar Brantsæter, Anne Lise Meltzer, Helle Margrete Alexander, Jan Haugen, Margaretha |
author_facet | Duarte-Salles, Talita von Stedingk, Hans Granum, Berit Gützkow, Kristine B. Rydberg, Per Törnqvist, Margareta Mendez, Michelle A. Brunborg, Gunnar Brantsæter, Anne Lise Meltzer, Helle Margrete Alexander, Jan Haugen, Margaretha |
author_sort | Duarte-Salles, Talita |
collection | PubMed |
description | Background: Acrylamide has shown developmental and reproductive toxicity in animals, as well as neurotoxic effects in humans with occupational exposures. Because it is widespread in food and can pass through the human placenta, concerns have been raised about potential developmental effects of dietary exposures in humans. Objectives: We assessed associations of prenatal exposure to dietary acrylamide with small for gestational age (SGA) and birth weight. Methods: This study included 50,651 women in the Norwegian Mother and Child Cohort Study (MoBa). Acrylamide exposure assessment was based on intake estimates obtained from a food frequency questionnaire (FFQ), which were compared with hemoglobin (Hb) adduct measurements reflecting acrylamide exposure in a subset of samples (n = 79). Data on infant birth weight and gestational age were obtained from the Medical Birth Registry of Norway. Multivariable regression was used to estimate associations between prenatal acrylamide and birth outcomes. Results: Acrylamide intake during pregnancy was negatively associated with fetal growth. When women in the highest quartile of acrylamide intake were compared with women in the lowest quartile, the multivariable-adjusted odds ratio (OR) for SGA was 1.11 (95% CI: 1.02, 1.21) and the coefficient for birth weight was –25.7 g (95% CI: –35.9, –15.4). Results were similar after excluding mothers who smoked during pregnancy. Maternal acrylamide– and glycidamide–Hb adduct levels were correlated with estimated dietary acrylamide intakes (Spearman correlations = 0.24; 95% CI: 0.02, 0.44; and 0.48; 95% CI: 0.29, 0.63, respectively). Conclusions: Lowering dietary acrylamide intake during pregnancy may improve fetal growth. |
format | Online Article Text |
id | pubmed-3621181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-36211812013-04-11 Dietary Acrylamide Intake during Pregnancy and Fetal Growth—Results from the Norwegian Mother and Child Cohort Study (MoBa) Duarte-Salles, Talita von Stedingk, Hans Granum, Berit Gützkow, Kristine B. Rydberg, Per Törnqvist, Margareta Mendez, Michelle A. Brunborg, Gunnar Brantsæter, Anne Lise Meltzer, Helle Margrete Alexander, Jan Haugen, Margaretha Environ Health Perspect Research Background: Acrylamide has shown developmental and reproductive toxicity in animals, as well as neurotoxic effects in humans with occupational exposures. Because it is widespread in food and can pass through the human placenta, concerns have been raised about potential developmental effects of dietary exposures in humans. Objectives: We assessed associations of prenatal exposure to dietary acrylamide with small for gestational age (SGA) and birth weight. Methods: This study included 50,651 women in the Norwegian Mother and Child Cohort Study (MoBa). Acrylamide exposure assessment was based on intake estimates obtained from a food frequency questionnaire (FFQ), which were compared with hemoglobin (Hb) adduct measurements reflecting acrylamide exposure in a subset of samples (n = 79). Data on infant birth weight and gestational age were obtained from the Medical Birth Registry of Norway. Multivariable regression was used to estimate associations between prenatal acrylamide and birth outcomes. Results: Acrylamide intake during pregnancy was negatively associated with fetal growth. When women in the highest quartile of acrylamide intake were compared with women in the lowest quartile, the multivariable-adjusted odds ratio (OR) for SGA was 1.11 (95% CI: 1.02, 1.21) and the coefficient for birth weight was –25.7 g (95% CI: –35.9, –15.4). Results were similar after excluding mothers who smoked during pregnancy. Maternal acrylamide– and glycidamide–Hb adduct levels were correlated with estimated dietary acrylamide intakes (Spearman correlations = 0.24; 95% CI: 0.02, 0.44; and 0.48; 95% CI: 0.29, 0.63, respectively). Conclusions: Lowering dietary acrylamide intake during pregnancy may improve fetal growth. National Institute of Environmental Health Sciences 2012-11-29 2013-03 /pmc/articles/PMC3621181/ /pubmed/23204292 http://dx.doi.org/10.1289/ehp.1205396 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Duarte-Salles, Talita von Stedingk, Hans Granum, Berit Gützkow, Kristine B. Rydberg, Per Törnqvist, Margareta Mendez, Michelle A. Brunborg, Gunnar Brantsæter, Anne Lise Meltzer, Helle Margrete Alexander, Jan Haugen, Margaretha Dietary Acrylamide Intake during Pregnancy and Fetal Growth—Results from the Norwegian Mother and Child Cohort Study (MoBa) |
title | Dietary Acrylamide Intake during Pregnancy and Fetal Growth—Results from the Norwegian Mother and Child Cohort Study (MoBa) |
title_full | Dietary Acrylamide Intake during Pregnancy and Fetal Growth—Results from the Norwegian Mother and Child Cohort Study (MoBa) |
title_fullStr | Dietary Acrylamide Intake during Pregnancy and Fetal Growth—Results from the Norwegian Mother and Child Cohort Study (MoBa) |
title_full_unstemmed | Dietary Acrylamide Intake during Pregnancy and Fetal Growth—Results from the Norwegian Mother and Child Cohort Study (MoBa) |
title_short | Dietary Acrylamide Intake during Pregnancy and Fetal Growth—Results from the Norwegian Mother and Child Cohort Study (MoBa) |
title_sort | dietary acrylamide intake during pregnancy and fetal growth—results from the norwegian mother and child cohort study (moba) |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621181/ https://www.ncbi.nlm.nih.gov/pubmed/23204292 http://dx.doi.org/10.1289/ehp.1205396 |
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