Transgenerational Inheritance of Increased Fat Depot Size, Stem Cell Reprogramming, and Hepatic Steatosis Elicited by Prenatal Exposure to the Obesogen Tributyltin in Mice

Background: We have previously shown that exposure to tributyltin (TBT) modulates critical steps of adipogenesis through RXR/PPARγ and that prenatal TBT exposure predisposes multipotent mesenchymal stem cells (MSCs) to become adipocytes by epigenetic imprinting into the memory of the MSC compartment...

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Detalles Bibliográficos
Autores principales: Chamorro-García, Raquel, Sahu, Margaret, Abbey, Rachelle J., Laude, Jhyme, Pham, Nhieu, Blumberg, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621201/
https://www.ncbi.nlm.nih.gov/pubmed/23322813
http://dx.doi.org/10.1289/ehp.1205701

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