Cargando…

Does Combination Therapy with Desmopressin and Tolterodine Improve the Treatment Outcomes of Patients with Monosymptomatic Nocturnal Enuresis? A Randomized Clinical Controlled Trial

Several therapeutic options have been described for children with nocturnal enuresis, but still their efficacy and outcomes are controversial. This study compares the combined Desmopressin and Tolterodine efficacy versus Desmopressin alone efficacy in the treatment of nocturnal enuresis. One hundred...

Descripción completa

Detalles Bibliográficos
Autores principales: Kazemi Rashed, Fahimeh, Nourizade, Davoud, Hajebrahimi, Sakineh, Hasanzade, Kamaleddin, Otoofat, Abdolreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621291/
https://www.ncbi.nlm.nih.gov/pubmed/23589779
http://dx.doi.org/10.1155/2013/413146
_version_ 1782265692450455552
author Kazemi Rashed, Fahimeh
Nourizade, Davoud
Hajebrahimi, Sakineh
Hasanzade, Kamaleddin
Otoofat, Abdolreza
author_facet Kazemi Rashed, Fahimeh
Nourizade, Davoud
Hajebrahimi, Sakineh
Hasanzade, Kamaleddin
Otoofat, Abdolreza
author_sort Kazemi Rashed, Fahimeh
collection PubMed
description Several therapeutic options have been described for children with nocturnal enuresis, but still their efficacy and outcomes are controversial. This study compares the combined Desmopressin and Tolterodine efficacy versus Desmopressin alone efficacy in the treatment of nocturnal enuresis. One hundred children 5–16 years old with nocturnal enuresis were enrolled in a randomized trial study and were assigned to two equal groups. In a double-blind manner, we used 2 mg of Tolterodine tablet plus 20 μg of nasal Desmopressin in group A and 20 μg of nasal Desmopressin plus placebo in group B. The two groups were matched for age and sex (P = 0.547, P = 0.414). The mean number of the wet nights was reduced in both groups (P < 0.001, P < 0.001). Upon ICCS scoring in the Tolterodine + Desmopressin group, 27 (54%) had full response, 17 (34%) had partial response, and 5 (10%) had an unsuccessful outcome. In the Desmopressin + placebo group, 17 (34%) had full response, 23 (46%) had partial response, and 10 (20%) had an unsuccessful outcome. The response in the Tolterodine + Desmopressin group was significantly higher (P = 0.049). Regarding the results, combined Tolterodine plus Desmopressin is slightly more effective than monotherapy.
format Online
Article
Text
id pubmed-3621291
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-36212912013-04-15 Does Combination Therapy with Desmopressin and Tolterodine Improve the Treatment Outcomes of Patients with Monosymptomatic Nocturnal Enuresis? A Randomized Clinical Controlled Trial Kazemi Rashed, Fahimeh Nourizade, Davoud Hajebrahimi, Sakineh Hasanzade, Kamaleddin Otoofat, Abdolreza ISRN Urol Research Article Several therapeutic options have been described for children with nocturnal enuresis, but still their efficacy and outcomes are controversial. This study compares the combined Desmopressin and Tolterodine efficacy versus Desmopressin alone efficacy in the treatment of nocturnal enuresis. One hundred children 5–16 years old with nocturnal enuresis were enrolled in a randomized trial study and were assigned to two equal groups. In a double-blind manner, we used 2 mg of Tolterodine tablet plus 20 μg of nasal Desmopressin in group A and 20 μg of nasal Desmopressin plus placebo in group B. The two groups were matched for age and sex (P = 0.547, P = 0.414). The mean number of the wet nights was reduced in both groups (P < 0.001, P < 0.001). Upon ICCS scoring in the Tolterodine + Desmopressin group, 27 (54%) had full response, 17 (34%) had partial response, and 5 (10%) had an unsuccessful outcome. In the Desmopressin + placebo group, 17 (34%) had full response, 23 (46%) had partial response, and 10 (20%) had an unsuccessful outcome. The response in the Tolterodine + Desmopressin group was significantly higher (P = 0.049). Regarding the results, combined Tolterodine plus Desmopressin is slightly more effective than monotherapy. Hindawi Publishing Corporation 2013-03-25 /pmc/articles/PMC3621291/ /pubmed/23589779 http://dx.doi.org/10.1155/2013/413146 Text en Copyright © 2013 Fahimeh Kazemi Rashed et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kazemi Rashed, Fahimeh
Nourizade, Davoud
Hajebrahimi, Sakineh
Hasanzade, Kamaleddin
Otoofat, Abdolreza
Does Combination Therapy with Desmopressin and Tolterodine Improve the Treatment Outcomes of Patients with Monosymptomatic Nocturnal Enuresis? A Randomized Clinical Controlled Trial
title Does Combination Therapy with Desmopressin and Tolterodine Improve the Treatment Outcomes of Patients with Monosymptomatic Nocturnal Enuresis? A Randomized Clinical Controlled Trial
title_full Does Combination Therapy with Desmopressin and Tolterodine Improve the Treatment Outcomes of Patients with Monosymptomatic Nocturnal Enuresis? A Randomized Clinical Controlled Trial
title_fullStr Does Combination Therapy with Desmopressin and Tolterodine Improve the Treatment Outcomes of Patients with Monosymptomatic Nocturnal Enuresis? A Randomized Clinical Controlled Trial
title_full_unstemmed Does Combination Therapy with Desmopressin and Tolterodine Improve the Treatment Outcomes of Patients with Monosymptomatic Nocturnal Enuresis? A Randomized Clinical Controlled Trial
title_short Does Combination Therapy with Desmopressin and Tolterodine Improve the Treatment Outcomes of Patients with Monosymptomatic Nocturnal Enuresis? A Randomized Clinical Controlled Trial
title_sort does combination therapy with desmopressin and tolterodine improve the treatment outcomes of patients with monosymptomatic nocturnal enuresis? a randomized clinical controlled trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621291/
https://www.ncbi.nlm.nih.gov/pubmed/23589779
http://dx.doi.org/10.1155/2013/413146
work_keys_str_mv AT kazemirashedfahimeh doescombinationtherapywithdesmopressinandtolterodineimprovethetreatmentoutcomesofpatientswithmonosymptomaticnocturnalenuresisarandomizedclinicalcontrolledtrial
AT nourizadedavoud doescombinationtherapywithdesmopressinandtolterodineimprovethetreatmentoutcomesofpatientswithmonosymptomaticnocturnalenuresisarandomizedclinicalcontrolledtrial
AT hajebrahimisakineh doescombinationtherapywithdesmopressinandtolterodineimprovethetreatmentoutcomesofpatientswithmonosymptomaticnocturnalenuresisarandomizedclinicalcontrolledtrial
AT hasanzadekamaleddin doescombinationtherapywithdesmopressinandtolterodineimprovethetreatmentoutcomesofpatientswithmonosymptomaticnocturnalenuresisarandomizedclinicalcontrolledtrial
AT otoofatabdolreza doescombinationtherapywithdesmopressinandtolterodineimprovethetreatmentoutcomesofpatientswithmonosymptomaticnocturnalenuresisarandomizedclinicalcontrolledtrial