Synthesis and characterization of some novel fatty acid analogues: A preliminary investigation on their activity against human lung carcinoma cell line

BACKGROUND: Preparation of some novel heterocyclic compounds with long alkyl and alkenyl chain of cytotoxic activity. METHODS: Gamma linolenic acid, a poly unsaturated fatty acid and stearic acid, a saturated fatty acid were isolated from the microalga Spirulina platensis. Some novel gamma linolenic...

Descripción completa

Detalles Bibliográficos
Autores principales: Jubie, Selvaraj, Dhanabal, Palanisamy, Afzal Azam, Mohammed, Muruganantham, Nithyanantham, Kalirajan, Rajagopal, Elango, Kannan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621780/
https://www.ncbi.nlm.nih.gov/pubmed/23537396
http://dx.doi.org/10.1186/1476-511X-12-45
_version_ 1782265760785104896
author Jubie, Selvaraj
Dhanabal, Palanisamy
Afzal Azam, Mohammed
Muruganantham, Nithyanantham
Kalirajan, Rajagopal
Elango, Kannan
author_facet Jubie, Selvaraj
Dhanabal, Palanisamy
Afzal Azam, Mohammed
Muruganantham, Nithyanantham
Kalirajan, Rajagopal
Elango, Kannan
author_sort Jubie, Selvaraj
collection PubMed
description BACKGROUND: Preparation of some novel heterocyclic compounds with long alkyl and alkenyl chain of cytotoxic activity. METHODS: Gamma linolenic acid, a poly unsaturated fatty acid and stearic acid, a saturated fatty acid were isolated from the microalga Spirulina platensis. Some novel gamma linolenic acid and stearic acid analogues having 1,3,4-oxadiazole and 1,2,4-triazole were synthesized and characterized by IR, (1)H NMR, (13)C NMR and mass spectral analysis. Cytotoxicity of these compounds was evaluated by the growth inhibition of A-549 cells in-vitro. RESULTS: Compound 1 and 3 showed comparable cytotoxicity against the human lung carcinoma A-549 cell lines.
format Online
Article
Text
id pubmed-3621780
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-36217802013-08-09 Synthesis and characterization of some novel fatty acid analogues: A preliminary investigation on their activity against human lung carcinoma cell line Jubie, Selvaraj Dhanabal, Palanisamy Afzal Azam, Mohammed Muruganantham, Nithyanantham Kalirajan, Rajagopal Elango, Kannan Lipids Health Dis Research BACKGROUND: Preparation of some novel heterocyclic compounds with long alkyl and alkenyl chain of cytotoxic activity. METHODS: Gamma linolenic acid, a poly unsaturated fatty acid and stearic acid, a saturated fatty acid were isolated from the microalga Spirulina platensis. Some novel gamma linolenic acid and stearic acid analogues having 1,3,4-oxadiazole and 1,2,4-triazole were synthesized and characterized by IR, (1)H NMR, (13)C NMR and mass spectral analysis. Cytotoxicity of these compounds was evaluated by the growth inhibition of A-549 cells in-vitro. RESULTS: Compound 1 and 3 showed comparable cytotoxicity against the human lung carcinoma A-549 cell lines. BioMed Central 2013-03-28 /pmc/articles/PMC3621780/ /pubmed/23537396 http://dx.doi.org/10.1186/1476-511X-12-45 Text en Copyright © 2013 Jubie et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Jubie, Selvaraj
Dhanabal, Palanisamy
Afzal Azam, Mohammed
Muruganantham, Nithyanantham
Kalirajan, Rajagopal
Elango, Kannan
Synthesis and characterization of some novel fatty acid analogues: A preliminary investigation on their activity against human lung carcinoma cell line
title Synthesis and characterization of some novel fatty acid analogues: A preliminary investigation on their activity against human lung carcinoma cell line
title_full Synthesis and characterization of some novel fatty acid analogues: A preliminary investigation on their activity against human lung carcinoma cell line
title_fullStr Synthesis and characterization of some novel fatty acid analogues: A preliminary investigation on their activity against human lung carcinoma cell line
title_full_unstemmed Synthesis and characterization of some novel fatty acid analogues: A preliminary investigation on their activity against human lung carcinoma cell line
title_short Synthesis and characterization of some novel fatty acid analogues: A preliminary investigation on their activity against human lung carcinoma cell line
title_sort synthesis and characterization of some novel fatty acid analogues: a preliminary investigation on their activity against human lung carcinoma cell line
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621780/
https://www.ncbi.nlm.nih.gov/pubmed/23537396
http://dx.doi.org/10.1186/1476-511X-12-45
work_keys_str_mv AT jubieselvaraj synthesisandcharacterizationofsomenovelfattyacidanaloguesapreliminaryinvestigationontheiractivityagainsthumanlungcarcinomacellline
AT dhanabalpalanisamy synthesisandcharacterizationofsomenovelfattyacidanaloguesapreliminaryinvestigationontheiractivityagainsthumanlungcarcinomacellline
AT afzalazammohammed synthesisandcharacterizationofsomenovelfattyacidanaloguesapreliminaryinvestigationontheiractivityagainsthumanlungcarcinomacellline
AT murugananthamnithyanantham synthesisandcharacterizationofsomenovelfattyacidanaloguesapreliminaryinvestigationontheiractivityagainsthumanlungcarcinomacellline
AT kalirajanrajagopal synthesisandcharacterizationofsomenovelfattyacidanaloguesapreliminaryinvestigationontheiractivityagainsthumanlungcarcinomacellline
AT elangokannan synthesisandcharacterizationofsomenovelfattyacidanaloguesapreliminaryinvestigationontheiractivityagainsthumanlungcarcinomacellline

Ejemplares similares