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One single method to produce native and Tat-fused recombinant human α-synuclein in Escherichia coli
BACKGROUND: Human α-synuclein is a small-sized, natively unfolded protein that in fibrillar form is the primary component of Lewy bodies, the pathological hallmark of Parkinson’s disease. Experimental evidence suggests that α-synuclein aggregation is the key event that triggers neurotoxicity althoug...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621789/ https://www.ncbi.nlm.nih.gov/pubmed/23557146 http://dx.doi.org/10.1186/1472-6750-13-32 |