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Determinants of Vitamin D Status in Fair-Skinned Women of Childbearing Age at Northern Latitudes

BACKGROUND AND OBJECTIVE: Poor vitamin D status during pregnancy has been associated with unfavorable outcomes for mother and child. Thus, adequate vitamin D status in women of childbearing age may be important. The aim of this study is to investigate the determinants of 25-hydroxyvitamin D (25(OH)D...

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Autores principales: Hedlund, Linnea, Brembeck, Petra, Olausson, Hanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621883/
https://www.ncbi.nlm.nih.gov/pubmed/23593333
http://dx.doi.org/10.1371/journal.pone.0060864
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author Hedlund, Linnea
Brembeck, Petra
Olausson, Hanna
author_facet Hedlund, Linnea
Brembeck, Petra
Olausson, Hanna
author_sort Hedlund, Linnea
collection PubMed
description BACKGROUND AND OBJECTIVE: Poor vitamin D status during pregnancy has been associated with unfavorable outcomes for mother and child. Thus, adequate vitamin D status in women of childbearing age may be important. The aim of this study is to investigate the determinants of 25-hydroxyvitamin D (25(OH)D) serum concentrations in women of childbearing age living in Sweden, at latitude 57–58° north. METHOD: Eighty four non-pregnant, non-lactating, healthy, fair-skinned women aged between 25–40 years were included. All subjects provided blood samples, four day food records and answered questionnaires about sun exposure and lifestyle. Total serum 25(OH)D was analyzed using Roche Cobas® electrochemoluminiescent immunoassay. RESULTS: Mean 25(OH)D was 65.8±19.9 nmol/l and 23% of the subjects had concentrations <50 nmol/l. Only 1% had concentrations <25 nmol/l. Determinants of 25(OH)D concentrations were recent sunbed use, recent travel to southern latitude, season, estrogen contraceptive use and use of supplementary vitamin D (R(2) = 0.27). CONCLUSION: Every fifth woman had 25(OH)D concentrations <50 nmol/l. About 30% of the variation in vitamin D status was explained by sun exposure, use of vitamin D supplements and use of estrogen contraceptives. Cutaneous vitamin D synthesis seems to be a major contributor to vitamin D status, even at northern latitudes. Thus, recommendations on safe UV-B exposure could be beneficial for vitamin D status.
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spelling pubmed-36218832013-04-16 Determinants of Vitamin D Status in Fair-Skinned Women of Childbearing Age at Northern Latitudes Hedlund, Linnea Brembeck, Petra Olausson, Hanna PLoS One Research Article BACKGROUND AND OBJECTIVE: Poor vitamin D status during pregnancy has been associated with unfavorable outcomes for mother and child. Thus, adequate vitamin D status in women of childbearing age may be important. The aim of this study is to investigate the determinants of 25-hydroxyvitamin D (25(OH)D) serum concentrations in women of childbearing age living in Sweden, at latitude 57–58° north. METHOD: Eighty four non-pregnant, non-lactating, healthy, fair-skinned women aged between 25–40 years were included. All subjects provided blood samples, four day food records and answered questionnaires about sun exposure and lifestyle. Total serum 25(OH)D was analyzed using Roche Cobas® electrochemoluminiescent immunoassay. RESULTS: Mean 25(OH)D was 65.8±19.9 nmol/l and 23% of the subjects had concentrations <50 nmol/l. Only 1% had concentrations <25 nmol/l. Determinants of 25(OH)D concentrations were recent sunbed use, recent travel to southern latitude, season, estrogen contraceptive use and use of supplementary vitamin D (R(2) = 0.27). CONCLUSION: Every fifth woman had 25(OH)D concentrations <50 nmol/l. About 30% of the variation in vitamin D status was explained by sun exposure, use of vitamin D supplements and use of estrogen contraceptives. Cutaneous vitamin D synthesis seems to be a major contributor to vitamin D status, even at northern latitudes. Thus, recommendations on safe UV-B exposure could be beneficial for vitamin D status. Public Library of Science 2013-04-09 /pmc/articles/PMC3621883/ /pubmed/23593333 http://dx.doi.org/10.1371/journal.pone.0060864 Text en © 2013 Hedlund et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hedlund, Linnea
Brembeck, Petra
Olausson, Hanna
Determinants of Vitamin D Status in Fair-Skinned Women of Childbearing Age at Northern Latitudes
title Determinants of Vitamin D Status in Fair-Skinned Women of Childbearing Age at Northern Latitudes
title_full Determinants of Vitamin D Status in Fair-Skinned Women of Childbearing Age at Northern Latitudes
title_fullStr Determinants of Vitamin D Status in Fair-Skinned Women of Childbearing Age at Northern Latitudes
title_full_unstemmed Determinants of Vitamin D Status in Fair-Skinned Women of Childbearing Age at Northern Latitudes
title_short Determinants of Vitamin D Status in Fair-Skinned Women of Childbearing Age at Northern Latitudes
title_sort determinants of vitamin d status in fair-skinned women of childbearing age at northern latitudes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621883/
https://www.ncbi.nlm.nih.gov/pubmed/23593333
http://dx.doi.org/10.1371/journal.pone.0060864
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