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Discovery of the Inhibitory Effect of a Phosphatidylinositol Derivative on P-Glycoprotein by Virtual Screening Followed by In Vitro Cellular Studies

P-glycoprotein is capable of effluxing a broad range of cytosolic and membrane penetrating xenobiotic substrates, thus leading to multi-drug resistance and posing a threat for the therapeutic treatment of several diseases, including cancer and central nervous disorders. Herein, a virtual screening c...

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Detalles Bibliográficos
Autores principales: Lucas, Xavier, Simon, Silke, Schubert, Rolf, Günther, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621910/
https://www.ncbi.nlm.nih.gov/pubmed/23593281
http://dx.doi.org/10.1371/journal.pone.0060679

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