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Differential Genetic and Epigenetic Regulation of catechol-O-methyltransferase is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder

The catechol-O-methyltransferase (COMT) enzyme is critical for the catabolic regulation of synaptic dopamine, resulting in altered cortical functioning. The COMT Val(158)Met polymorphism has been implicated in human mental illness, with Met/Met homozygotes associated with increased susceptibility to...

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Detalles Bibliográficos
Autores principales:	Norrholm, Seth Davin, Jovanovic, Tanja, Smith, Alicia K., Binder, Elisabeth, Klengel, Torsten, Conneely, Karen, Mercer, Kristina B., Davis, Jennifer S., Kerley, Kimberly, Winkler, Jennifer, Gillespie, Charles F., Bradley, Bekh, Ressler, Kerry J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622057/ https://www.ncbi.nlm.nih.gov/pubmed/23596403 http://dx.doi.org/10.3389/fnbeh.2013.00030

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