SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion

The secretory pathway of eukaryotic cells packages cargo proteins into COPII-coated vesicles for transport from the endoplasmic reticulum (ER) to the Golgi. We now report that complete genetic deficiency for the COPII component SEC24A is compatible with normal survival and development in the mouse,...

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Detalles Bibliográficos
Autores principales: Chen, Xiao-Wei, Wang, He, Bajaj, Kanika, Zhang, Pengcheng, Meng, Zhuo-Xian, Ma, Danjun, Bai, Yongsheng, Liu, Hui-Hui, Adams, Elizabeth, Baines, Andrea, Yu, Genggeng, Sartor, Maureen A, Zhang, Bin, Yi, Zhengping, Lin, Jiandie, Young, Stephen G, Schekman, Randy, Ginsburg, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622177/
https://www.ncbi.nlm.nih.gov/pubmed/23580231
http://dx.doi.org/10.7554/eLife.00444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622177/
https://www.ncbi.nlm.nih.gov/pubmed/23580231
http://dx.doi.org/10.7554/eLife.00444

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