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Shedding new light on circadian clocks

Using a clever combination of genetic and biochemical tools researchers have shown that a transcription factor called USF1 has a central role in determining how mutations of the Clock gene manifest themselves in the behaviour of different mouse strains.

Detalles Bibliográficos
Autores principales: Demarque, Maud, Schibler, Ueli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622228/
https://www.ncbi.nlm.nih.gov/pubmed/23580350
http://dx.doi.org/10.7554/eLife.00659
Descripción
Sumario:Using a clever combination of genetic and biochemical tools researchers have shown that a transcription factor called USF1 has a central role in determining how mutations of the Clock gene manifest themselves in the behaviour of different mouse strains.