Rapid Evolutionary Dynamics of Structural Disorder as a Potential Driving Force for Biological Divergence in Flaviviruses

Protein structure is commonly regarded to be conserved and to dictate function. Most proteins rely on conformational flexibility to some degree. Are regions that convey conformational flexibility conserved over evolutionary time? Can changes in conformational flexibility alter protein function? Here...

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Detalles Bibliográficos
Autores principales: Ortiz, Juan F., MacDonald, Madolyn L., Masterson, Patrick, Uversky, Vladimir N., Siltberg-Liberles, Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622304/
https://www.ncbi.nlm.nih.gov/pubmed/23418179
http://dx.doi.org/10.1093/gbe/evt026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622304/
https://www.ncbi.nlm.nih.gov/pubmed/23418179
http://dx.doi.org/10.1093/gbe/evt026

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