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The effect of weight in the outcomes of meningioma patients

BACKGROUND: Meningiomas are more prevalent in women and mostly benign in nature. Our aim was to evaluate the association of weight and outcomes of meningioma patients undergoing craniotomy. METHODS: A retrospective analysis of meningioma patients discharged postcraniotomy between 1998 and 2007 was c...

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Autores principales: Dickinson, Holly, Carico, Christine, Nuño, Miriam, Nosova, Kristin, Elramsisy, Adam, Patil, Chirag G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622350/
https://www.ncbi.nlm.nih.gov/pubmed/23607067
http://dx.doi.org/10.4103/2152-7806.110023
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author Dickinson, Holly
Carico, Christine
Nuño, Miriam
Nosova, Kristin
Elramsisy, Adam
Patil, Chirag G.
author_facet Dickinson, Holly
Carico, Christine
Nuño, Miriam
Nosova, Kristin
Elramsisy, Adam
Patil, Chirag G.
author_sort Dickinson, Holly
collection PubMed
description BACKGROUND: Meningiomas are more prevalent in women and mostly benign in nature. Our aim was to evaluate the association of weight and outcomes of meningioma patients undergoing craniotomy. METHODS: A retrospective analysis of meningioma patients discharged postcraniotomy between 1998 and 2007 was conducted. Univariate and multivariate analysis evaluated in-hospital mortality, complications, length of stay (LOS), and cost. RESULTS: According to the nationwide inpatient sample (NIS) database, an estimated 72,257 adult meningioma patients underwent a craniotomy in US hospitals during the study period. Female and male weight loss rates were 0.7% and 1.2%, respectively; obesity rates were 5.2% and 3.7%. Males had higher rates of malignant tumors than females (6.2% vs. 3.5%, P < 0.0001), and malignant tumors were more common in patients with weight loss (6.4% vs. 4.3%, P = 0.03). Weight loss was associated with higher mortality in men (OR 6.66, P < 0.0001) and women (OR 3.92, P = 0.04) as well as higher rates of postoperative complications in both men (OR 6.13, P < 0.0001) and women (OR 8.37, P < 0.0001). Furthermore, patients suffering weight loss had longer LOS and higher overall hospital cost when compared with all patients. In contrast, obesity seemed to reduce mortality (OR 0.47, P = 0.0006) and complications (OR 0.8, P = 0.0007) among women. CONCLUSIONS: In summary, weight loss seems to be the single most critical factor present in patients experiencing higher mortality, complications, hospital charges, and longer LOS. However, further studies aimed to assess the inter-relation of potential preexisting comorbidities and weight loss are needed to establish causation.
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spelling pubmed-36223502013-04-19 The effect of weight in the outcomes of meningioma patients Dickinson, Holly Carico, Christine Nuño, Miriam Nosova, Kristin Elramsisy, Adam Patil, Chirag G. Surg Neurol Int Original Article BACKGROUND: Meningiomas are more prevalent in women and mostly benign in nature. Our aim was to evaluate the association of weight and outcomes of meningioma patients undergoing craniotomy. METHODS: A retrospective analysis of meningioma patients discharged postcraniotomy between 1998 and 2007 was conducted. Univariate and multivariate analysis evaluated in-hospital mortality, complications, length of stay (LOS), and cost. RESULTS: According to the nationwide inpatient sample (NIS) database, an estimated 72,257 adult meningioma patients underwent a craniotomy in US hospitals during the study period. Female and male weight loss rates were 0.7% and 1.2%, respectively; obesity rates were 5.2% and 3.7%. Males had higher rates of malignant tumors than females (6.2% vs. 3.5%, P < 0.0001), and malignant tumors were more common in patients with weight loss (6.4% vs. 4.3%, P = 0.03). Weight loss was associated with higher mortality in men (OR 6.66, P < 0.0001) and women (OR 3.92, P = 0.04) as well as higher rates of postoperative complications in both men (OR 6.13, P < 0.0001) and women (OR 8.37, P < 0.0001). Furthermore, patients suffering weight loss had longer LOS and higher overall hospital cost when compared with all patients. In contrast, obesity seemed to reduce mortality (OR 0.47, P = 0.0006) and complications (OR 0.8, P = 0.0007) among women. CONCLUSIONS: In summary, weight loss seems to be the single most critical factor present in patients experiencing higher mortality, complications, hospital charges, and longer LOS. However, further studies aimed to assess the inter-relation of potential preexisting comorbidities and weight loss are needed to establish causation. Medknow Publications & Media Pvt Ltd 2013-04-03 /pmc/articles/PMC3622350/ /pubmed/23607067 http://dx.doi.org/10.4103/2152-7806.110023 Text en Copyright: © 2013 Dickinson H http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Dickinson, Holly
Carico, Christine
Nuño, Miriam
Nosova, Kristin
Elramsisy, Adam
Patil, Chirag G.
The effect of weight in the outcomes of meningioma patients
title The effect of weight in the outcomes of meningioma patients
title_full The effect of weight in the outcomes of meningioma patients
title_fullStr The effect of weight in the outcomes of meningioma patients
title_full_unstemmed The effect of weight in the outcomes of meningioma patients
title_short The effect of weight in the outcomes of meningioma patients
title_sort effect of weight in the outcomes of meningioma patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622350/
https://www.ncbi.nlm.nih.gov/pubmed/23607067
http://dx.doi.org/10.4103/2152-7806.110023
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