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Age-Dependent Impairment of Eyeblink Conditioning in Prion Protein-Deficient Mice

Mice lacking the prion protein (PrP(C)) gene (Prnp), Ngsk Prnp (0/0) mice, show late-onset cerebellar Purkinje cell (PC) degeneration because of ectopic overexpression of PrP(C)-like protein (PrPLP/Dpl). Because PrP(C) is highly expressed in cerebellar neurons (including PCs and granule cells), it m...

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Detalles Bibliográficos
Autores principales:	Kishimoto, Yasushi, Hirono, Moritoshi, Atarashi, Ryuichiro, Sakaguchi, Suehiro, Yoshioka, Tohru, Katamine, Shigeru, Kirino, Yutaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622692/ https://www.ncbi.nlm.nih.gov/pubmed/23593266 http://dx.doi.org/10.1371/journal.pone.0060627

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