Cargando…

Clinical features and outcomes of gastric variceal bleeding: retrospective Korean multicenter data

BACKGROUND/AIMS: While gastric variceal bleeding (GVB) is not as prevalent as esophageal variceal bleeding, it is reportedly more serious, with high failure rates of the initial hemostasis (>30%), and has a worse prognosis than esophageal variceal bleeding. However, there is limited information r...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Moon Young, Um, Soon Ho, Baik, Soon Koo, Seo, Yeon Seok, Park, Soo Young, Lee, Jung Il, Lee, Jin Woo, Cheon, Gab Jin, Sohn, Joo Hyun, Kim, Tae Yeob, Lim, Young Suk, Kim, Tae Hyo, Lee, Tae Hee, Park, Sung Jae, Park, Seung Ha, Kim, Jin Dong, Han, Sang Young, Choi, Chang Soo, Cho, Eun Young, Kim, Dong Joon, Hwang, Jae Seok, Jang, Byoung Kuk, Lee, June Sung, Kim, Sang Gyune, Kim, Young Seok, Kwon, So Young, Choe, Won Hyeok, Lee, Chang Hyeong, Kim, Byung Seok, Jang, Jae Young, Jeong, Soung Won, Kim, Byung Ho, Shim, Jae Jun, Cho, Yong Kyun, Koh, Moon Soo, Lee, Hyun Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association for the Study of the Liver 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622854/
https://www.ncbi.nlm.nih.gov/pubmed/23593608
http://dx.doi.org/10.3350/cmh.2013.19.1.36
_version_ 1782265876977811456
author Kim, Moon Young
Um, Soon Ho
Baik, Soon Koo
Seo, Yeon Seok
Park, Soo Young
Lee, Jung Il
Lee, Jin Woo
Cheon, Gab Jin
Sohn, Joo Hyun
Kim, Tae Yeob
Lim, Young Suk
Kim, Tae Hyo
Lee, Tae Hee
Park, Sung Jae
Park, Seung Ha
Kim, Jin Dong
Han, Sang Young
Choi, Chang Soo
Cho, Eun Young
Kim, Dong Joon
Hwang, Jae Seok
Jang, Byoung Kuk
Lee, June Sung
Kim, Sang Gyune
Kim, Young Seok
Kwon, So Young
Choe, Won Hyeok
Lee, Chang Hyeong
Kim, Byung Seok
Jang, Jae Young
Jeong, Soung Won
Kim, Byung Ho
Shim, Jae Jun
Cho, Yong Kyun
Koh, Moon Soo
Lee, Hyun Woong
author_facet Kim, Moon Young
Um, Soon Ho
Baik, Soon Koo
Seo, Yeon Seok
Park, Soo Young
Lee, Jung Il
Lee, Jin Woo
Cheon, Gab Jin
Sohn, Joo Hyun
Kim, Tae Yeob
Lim, Young Suk
Kim, Tae Hyo
Lee, Tae Hee
Park, Sung Jae
Park, Seung Ha
Kim, Jin Dong
Han, Sang Young
Choi, Chang Soo
Cho, Eun Young
Kim, Dong Joon
Hwang, Jae Seok
Jang, Byoung Kuk
Lee, June Sung
Kim, Sang Gyune
Kim, Young Seok
Kwon, So Young
Choe, Won Hyeok
Lee, Chang Hyeong
Kim, Byung Seok
Jang, Jae Young
Jeong, Soung Won
Kim, Byung Ho
Shim, Jae Jun
Cho, Yong Kyun
Koh, Moon Soo
Lee, Hyun Woong
author_sort Kim, Moon Young
collection PubMed
description BACKGROUND/AIMS: While gastric variceal bleeding (GVB) is not as prevalent as esophageal variceal bleeding, it is reportedly more serious, with high failure rates of the initial hemostasis (>30%), and has a worse prognosis than esophageal variceal bleeding. However, there is limited information regarding hemostasis and the prognosis for GVB. The aim of this study was to determine retrospectively the clinical outcomes of GVB in a multicenter study in Korea. METHODS: The data of 1,308 episodes of GVB (males:females=1062:246, age=55.0±11.0 years, mean±SD) were collected from 24 referral hospital centers in South Korea between March 2003 and December 2008. The rates of initial hemostasis failure, rebleeding, and mortality within 5 days and 6 weeks of the index bleed were evaluated. RESULTS: The initial hemostasis failed in 6.1% of the patients, and this was associated with the Child-Pugh score [odds ratio (OR)=1.619; P<0.001] and the treatment modality: endoscopic variceal ligation, endoscopic variceal obturation, and balloon-occluded retrograde transvenous obliteration vs. endoscopic sclerotherapy, transjugular intrahepatic portosystemic shunt, and balloon tamponade (OR=0.221, P<0.001). Rebleeding developed in 11.5% of the patients, and was significantly associated with Child-Pugh score (OR=1.159, P<0.001) and treatment modality (OR=0.619, P=0.026). The GVB-associated mortality was 10.3%; mortality in these cases was associated with Child-Pugh score (OR=1.795, P<0.001) and the treatment modality for the initial hemostasis (OR=0.467, P=0.001). CONCLUSIONS: The clinical outcome for GVB was better for the present cohort than in previous reports. Initial hemostasis failure, rebleeding, and mortality due to GVB were universally associated with the severity of liver cirrhosis.
format Online
Article
Text
id pubmed-3622854
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher The Korean Association for the Study of the Liver
record_format MEDLINE/PubMed
spelling pubmed-36228542013-04-16 Clinical features and outcomes of gastric variceal bleeding: retrospective Korean multicenter data Kim, Moon Young Um, Soon Ho Baik, Soon Koo Seo, Yeon Seok Park, Soo Young Lee, Jung Il Lee, Jin Woo Cheon, Gab Jin Sohn, Joo Hyun Kim, Tae Yeob Lim, Young Suk Kim, Tae Hyo Lee, Tae Hee Park, Sung Jae Park, Seung Ha Kim, Jin Dong Han, Sang Young Choi, Chang Soo Cho, Eun Young Kim, Dong Joon Hwang, Jae Seok Jang, Byoung Kuk Lee, June Sung Kim, Sang Gyune Kim, Young Seok Kwon, So Young Choe, Won Hyeok Lee, Chang Hyeong Kim, Byung Seok Jang, Jae Young Jeong, Soung Won Kim, Byung Ho Shim, Jae Jun Cho, Yong Kyun Koh, Moon Soo Lee, Hyun Woong Clin Mol Hepatol Original Article BACKGROUND/AIMS: While gastric variceal bleeding (GVB) is not as prevalent as esophageal variceal bleeding, it is reportedly more serious, with high failure rates of the initial hemostasis (>30%), and has a worse prognosis than esophageal variceal bleeding. However, there is limited information regarding hemostasis and the prognosis for GVB. The aim of this study was to determine retrospectively the clinical outcomes of GVB in a multicenter study in Korea. METHODS: The data of 1,308 episodes of GVB (males:females=1062:246, age=55.0±11.0 years, mean±SD) were collected from 24 referral hospital centers in South Korea between March 2003 and December 2008. The rates of initial hemostasis failure, rebleeding, and mortality within 5 days and 6 weeks of the index bleed were evaluated. RESULTS: The initial hemostasis failed in 6.1% of the patients, and this was associated with the Child-Pugh score [odds ratio (OR)=1.619; P<0.001] and the treatment modality: endoscopic variceal ligation, endoscopic variceal obturation, and balloon-occluded retrograde transvenous obliteration vs. endoscopic sclerotherapy, transjugular intrahepatic portosystemic shunt, and balloon tamponade (OR=0.221, P<0.001). Rebleeding developed in 11.5% of the patients, and was significantly associated with Child-Pugh score (OR=1.159, P<0.001) and treatment modality (OR=0.619, P=0.026). The GVB-associated mortality was 10.3%; mortality in these cases was associated with Child-Pugh score (OR=1.795, P<0.001) and the treatment modality for the initial hemostasis (OR=0.467, P=0.001). CONCLUSIONS: The clinical outcome for GVB was better for the present cohort than in previous reports. Initial hemostasis failure, rebleeding, and mortality due to GVB were universally associated with the severity of liver cirrhosis. The Korean Association for the Study of the Liver 2013-03 2013-03-25 /pmc/articles/PMC3622854/ /pubmed/23593608 http://dx.doi.org/10.3350/cmh.2013.19.1.36 Text en Copyright © 2013 by The Korean Association for the Study of the Liver http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Moon Young
Um, Soon Ho
Baik, Soon Koo
Seo, Yeon Seok
Park, Soo Young
Lee, Jung Il
Lee, Jin Woo
Cheon, Gab Jin
Sohn, Joo Hyun
Kim, Tae Yeob
Lim, Young Suk
Kim, Tae Hyo
Lee, Tae Hee
Park, Sung Jae
Park, Seung Ha
Kim, Jin Dong
Han, Sang Young
Choi, Chang Soo
Cho, Eun Young
Kim, Dong Joon
Hwang, Jae Seok
Jang, Byoung Kuk
Lee, June Sung
Kim, Sang Gyune
Kim, Young Seok
Kwon, So Young
Choe, Won Hyeok
Lee, Chang Hyeong
Kim, Byung Seok
Jang, Jae Young
Jeong, Soung Won
Kim, Byung Ho
Shim, Jae Jun
Cho, Yong Kyun
Koh, Moon Soo
Lee, Hyun Woong
Clinical features and outcomes of gastric variceal bleeding: retrospective Korean multicenter data
title Clinical features and outcomes of gastric variceal bleeding: retrospective Korean multicenter data
title_full Clinical features and outcomes of gastric variceal bleeding: retrospective Korean multicenter data
title_fullStr Clinical features and outcomes of gastric variceal bleeding: retrospective Korean multicenter data
title_full_unstemmed Clinical features and outcomes of gastric variceal bleeding: retrospective Korean multicenter data
title_short Clinical features and outcomes of gastric variceal bleeding: retrospective Korean multicenter data
title_sort clinical features and outcomes of gastric variceal bleeding: retrospective korean multicenter data
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622854/
https://www.ncbi.nlm.nih.gov/pubmed/23593608
http://dx.doi.org/10.3350/cmh.2013.19.1.36
work_keys_str_mv AT kimmoonyoung clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT umsoonho clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT baiksoonkoo clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT seoyeonseok clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT parksooyoung clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT leejungil clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT leejinwoo clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT cheongabjin clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT sohnjoohyun clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT kimtaeyeob clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT limyoungsuk clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT kimtaehyo clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT leetaehee clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT parksungjae clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT parkseungha clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT kimjindong clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT hansangyoung clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT choichangsoo clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT choeunyoung clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT kimdongjoon clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT hwangjaeseok clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT jangbyoungkuk clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT leejunesung clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT kimsanggyune clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT kimyoungseok clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT kwonsoyoung clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT choewonhyeok clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT leechanghyeong clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT kimbyungseok clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT jangjaeyoung clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT jeongsoungwon clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT kimbyungho clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT shimjaejun clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT choyongkyun clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT kohmoonsoo clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata
AT leehyunwoong clinicalfeaturesandoutcomesofgastricvaricealbleedingretrospectivekoreanmulticenterdata