Two cases of telbivudine-induced myopathy in siblings with chronic hepatitis B

Telbivudine is an L-nucleoside analogue with potent antiviral activity against hepatitis B virus (HBV). Clinical trials have shown that telbivudine has a more potent and sustained antiviral activity with a lower frequency of viral resistance than lamivudine. Although there are several reports concer...

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Detalles Bibliográficos
Autores principales: Kim, Eun Hye, Park, Hana, Lee, Kun Ho, Ahn, Sang Hoon, Kim, Seung-Min, Han, Kwang-Hyub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association for the Study of the Liver 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622860/
https://www.ncbi.nlm.nih.gov/pubmed/23593614
http://dx.doi.org/10.3350/cmh.2013.19.1.82
Descripción
Sumario:Telbivudine is an L-nucleoside analogue with potent antiviral activity against hepatitis B virus (HBV). Clinical trials have shown that telbivudine has a more potent and sustained antiviral activity with a lower frequency of viral resistance than lamivudine. Although there are several reports concerning the safety profile of telbivudine, most adverse events are described as mild and transient in nature. Here we report two cases of telbivudine-induced myopathy in patients with chronic hepatitis B who were siblings.

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