Cargando…

Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques

In this manuscript we present novel MRI approaches to dissecting axon vs. myelin abnormalities in psychiatric disorders. Existing DTI approaches are not able to provide specific information on these subcellular elements but novel approaches are beginning to do so. We review two approaches (magnetiza...

Descripción completa

Detalles Bibliográficos
Autores principales: Du, Fei, Öngür, Dost
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622889/
https://www.ncbi.nlm.nih.gov/pubmed/23596402
http://dx.doi.org/10.3389/fnint.2013.00024
_version_ 1782265882149388288
author Du, Fei
Öngür, Dost
author_facet Du, Fei
Öngür, Dost
author_sort Du, Fei
collection PubMed
description In this manuscript we present novel MRI approaches to dissecting axon vs. myelin abnormalities in psychiatric disorders. Existing DTI approaches are not able to provide specific information on these subcellular elements but novel approaches are beginning to do so. We review two approaches (magnetization transfer ratio—MTR; and diffusion tensor spectroscopy—DTS) and the theoretical framework for interpreting data derived from these approaches. Work is ongoing to collect data that will answer some relevant questions using these techniques in schizophrenia and related conditions.
format Online
Article
Text
id pubmed-3622889
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-36228892013-04-17 Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques Du, Fei Öngür, Dost Front Integr Neurosci Neuroscience In this manuscript we present novel MRI approaches to dissecting axon vs. myelin abnormalities in psychiatric disorders. Existing DTI approaches are not able to provide specific information on these subcellular elements but novel approaches are beginning to do so. We review two approaches (magnetization transfer ratio—MTR; and diffusion tensor spectroscopy—DTS) and the theoretical framework for interpreting data derived from these approaches. Work is ongoing to collect data that will answer some relevant questions using these techniques in schizophrenia and related conditions. Frontiers Media S.A. 2013-04-11 /pmc/articles/PMC3622889/ /pubmed/23596402 http://dx.doi.org/10.3389/fnint.2013.00024 Text en Copyright © 2013 Du and Öngür. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
Du, Fei
Öngür, Dost
Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques
title Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques
title_full Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques
title_fullStr Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques
title_full_unstemmed Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques
title_short Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques
title_sort probing myelin and axon abnormalities separately in psychiatric disorders using mri techniques
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622889/
https://www.ncbi.nlm.nih.gov/pubmed/23596402
http://dx.doi.org/10.3389/fnint.2013.00024
work_keys_str_mv AT dufei probingmyelinandaxonabnormalitiesseparatelyinpsychiatricdisordersusingmritechniques
AT ongurdost probingmyelinandaxonabnormalitiesseparatelyinpsychiatricdisordersusingmritechniques