Inhibition of Viral Pathogenesis and Promotion of the Septic Shock Response to Bacterial Infection by IRF-3 Are Regulated by the Acetylation and Phosphorylation of Its Coactivators

Interferon (IFN) is required for protecting mice from viral pathogenesis; reciprocally, it mediates the deleterious septic shock response to bacterial infection. The critical transcription factor for IFN induction, in both cases, is IRF-3, which is activated by TLR3 or RIG-I signaling in response to...

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Detalles Bibliográficos
Autores principales: Chattopadhyay, Saurabh, Fensterl, Volker, Zhang, Ying, Veleeparambil, Manoj, Wetzel, Jaime L., Sen, Ganes C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622923/
https://www.ncbi.nlm.nih.gov/pubmed/23532979
http://dx.doi.org/10.1128/mBio.00636-12

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