Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease

Autosomal-dominant Alzheimer disease (ADAD) is a genetic disorder caused by mutations in Amyloid Precursor Protein (APP) or Presenilin (PSEN) genes. Studies from families with ADAD have been critical to support the amyloid cascade hypothesis of Alzheimer disease (AD), the basis for the current devel...

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Detalles Bibliográficos
Autores principales: Pera, Marta, Alcolea, Daniel, Sánchez-Valle, Raquel, Guardia-Laguarta, Cristina, Colom-Cadena, Martí, Badiola, Nahuai, Suárez-Calvet, Marc, Lladó, Albert, Barrera-Ocampo, Alvaro A., Sepulveda-Falla, Diego, Blesa, Rafael, Molinuevo, José L., Clarimón, Jordi, Ferrer, Isidre, Gelpi, Ellen, Lleó, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623032/
https://www.ncbi.nlm.nih.gov/pubmed/23224319
http://dx.doi.org/10.1007/s00401-012-1062-9

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