Tolerance to nitroglycerin through proteasomal down-regulation of aldehyde dehydrogenase-2 in a genetic mouse model of ascorbate deficiency

BACKGROUND AND PURPOSE: L-gulonolactone oxidase-deficient (Gulo((-/-))) mice were used to study the effects of ascorbate deficiency on aortic relaxation by nitroglycerin (GTN) with focus on changes in the expression and activity of vascular aldehyde dehydrogenase-2 (ALDH2), which catalyses GTN bioac...

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Detalles Bibliográficos
Autores principales: Wölkart, G, Beretta, M, Wenzl, MV, Stessel, H, Schmidt, K, Maeda, N, Mayer, B, Schrammel, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623057/
https://www.ncbi.nlm.nih.gov/pubmed/23194305
http://dx.doi.org/10.1111/bph.12081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623057/
https://www.ncbi.nlm.nih.gov/pubmed/23194305
http://dx.doi.org/10.1111/bph.12081

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