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Tolerance to nitroglycerin through proteasomal down-regulation of aldehyde dehydrogenase-2 in a genetic mouse model of ascorbate deficiency

BACKGROUND AND PURPOSE: L-gulonolactone oxidase-deficient (Gulo((-/-))) mice were used to study the effects of ascorbate deficiency on aortic relaxation by nitroglycerin (GTN) with focus on changes in the expression and activity of vascular aldehyde dehydrogenase-2 (ALDH2), which catalyses GTN bioac...

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Detalles Bibliográficos
Autores principales:	Wölkart, G, Beretta, M, Wenzl, MV, Stessel, H, Schmidt, K, Maeda, N, Mayer, B, Schrammel, A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2013
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623057/ https://www.ncbi.nlm.nih.gov/pubmed/23194305 http://dx.doi.org/10.1111/bph.12081

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