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Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma
Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. Here, we describe the technique of using...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623468/ https://www.ncbi.nlm.nih.gov/pubmed/23606830 http://dx.doi.org/10.1155/2013/207129 |
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author | Shirley, Lawrence A. Aguilar, Laura K. Aguilar-Cordova, Estuardo Bloomston, Mark Walker, Jon P. |
author_facet | Shirley, Lawrence A. Aguilar, Laura K. Aguilar-Cordova, Estuardo Bloomston, Mark Walker, Jon P. |
author_sort | Shirley, Lawrence A. |
collection | PubMed |
description | Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. Here, we describe the technique of using endoscopic ultrasound in order to directly inject both novel and conventional therapies into pancreatic tumors. We detail the rationale behind this strategy and the many benefits it provides. We then describe our technique in detail, including our experience injecting the AdV-tk adenoviral vector to create an in situ vaccine effect. |
format | Online Article Text |
id | pubmed-3623468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36234682013-04-19 Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma Shirley, Lawrence A. Aguilar, Laura K. Aguilar-Cordova, Estuardo Bloomston, Mark Walker, Jon P. Gastroenterol Res Pract Methodology Report Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. Here, we describe the technique of using endoscopic ultrasound in order to directly inject both novel and conventional therapies into pancreatic tumors. We detail the rationale behind this strategy and the many benefits it provides. We then describe our technique in detail, including our experience injecting the AdV-tk adenoviral vector to create an in situ vaccine effect. Hindawi Publishing Corporation 2013 2013-03-27 /pmc/articles/PMC3623468/ /pubmed/23606830 http://dx.doi.org/10.1155/2013/207129 Text en Copyright © 2013 Lawrence A. Shirley et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Methodology Report Shirley, Lawrence A. Aguilar, Laura K. Aguilar-Cordova, Estuardo Bloomston, Mark Walker, Jon P. Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma |
title | Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma |
title_full | Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma |
title_fullStr | Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma |
title_full_unstemmed | Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma |
title_short | Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma |
title_sort | therapeutic endoscopic ultrasonography: intratumoral injection for pancreatic adenocarcinoma |
topic | Methodology Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623468/ https://www.ncbi.nlm.nih.gov/pubmed/23606830 http://dx.doi.org/10.1155/2013/207129 |
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