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Mucosal vaccine adjuvants update
Mucosal vaccination, capable of inducing protective immune responses both in the mucosal and systemic immune compartments, has many advantages and is regarded as a blue ocean in the vaccine industry. Mucosal vaccines can offer lower costs, better accessability, needle-free delivery, and higher capac...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Vaccine Society
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623511/ https://www.ncbi.nlm.nih.gov/pubmed/23596577 http://dx.doi.org/10.7774/cevr.2012.1.1.50 |
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author | Rhee, Joon Haeng Lee, Shee Eun Kim, Soo Young |
author_facet | Rhee, Joon Haeng Lee, Shee Eun Kim, Soo Young |
author_sort | Rhee, Joon Haeng |
collection | PubMed |
description | Mucosal vaccination, capable of inducing protective immune responses both in the mucosal and systemic immune compartments, has many advantages and is regarded as a blue ocean in the vaccine industry. Mucosal vaccines can offer lower costs, better accessability, needle-free delivery, and higher capacity of mass immunizations during pandemics. However, only very limited number of mucosal vaccines was approved for human use in the market yet. Generally, induction of immune responses following mucosal immunization requires the co-administration of appropriate adjuvants that can initiate and support the effective collaboration between innate and adaptive immunity. Classically, adjuvant researches were rather empirical than keenly scientific. However, during last several years, fundamental scientific achievements in innate immunity have been translated into the development of new mucosal adjuvants. This review focuses on recent developments in the concepts of adjuvants and innate immunity, mucosal immunity with special interest of vaccine development, and basic and applied researches in mucosal adjuvant. |
format | Online Article Text |
id | pubmed-3623511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Vaccine Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-36235112013-04-17 Mucosal vaccine adjuvants update Rhee, Joon Haeng Lee, Shee Eun Kim, Soo Young Clin Exp Vaccine Res Review Article Mucosal vaccination, capable of inducing protective immune responses both in the mucosal and systemic immune compartments, has many advantages and is regarded as a blue ocean in the vaccine industry. Mucosal vaccines can offer lower costs, better accessability, needle-free delivery, and higher capacity of mass immunizations during pandemics. However, only very limited number of mucosal vaccines was approved for human use in the market yet. Generally, induction of immune responses following mucosal immunization requires the co-administration of appropriate adjuvants that can initiate and support the effective collaboration between innate and adaptive immunity. Classically, adjuvant researches were rather empirical than keenly scientific. However, during last several years, fundamental scientific achievements in innate immunity have been translated into the development of new mucosal adjuvants. This review focuses on recent developments in the concepts of adjuvants and innate immunity, mucosal immunity with special interest of vaccine development, and basic and applied researches in mucosal adjuvant. The Korean Vaccine Society 2012-07 2012-07-31 /pmc/articles/PMC3623511/ /pubmed/23596577 http://dx.doi.org/10.7774/cevr.2012.1.1.50 Text en © Korean Vaccine Society. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Rhee, Joon Haeng Lee, Shee Eun Kim, Soo Young Mucosal vaccine adjuvants update |
title | Mucosal vaccine adjuvants update |
title_full | Mucosal vaccine adjuvants update |
title_fullStr | Mucosal vaccine adjuvants update |
title_full_unstemmed | Mucosal vaccine adjuvants update |
title_short | Mucosal vaccine adjuvants update |
title_sort | mucosal vaccine adjuvants update |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623511/ https://www.ncbi.nlm.nih.gov/pubmed/23596577 http://dx.doi.org/10.7774/cevr.2012.1.1.50 |
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