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Antipsychotic-Induced Sexual Dysfunction and Its Management
Sexual dysfunction is a common condition in patients taking antipsychotics, and is the most bothersome symptom and adverse drug effect, resulting in a negative effect on treatment compliance. It is known that hyperprolactinemia is a major cause of sexual dysfunction. Based on the blockade of dopamin...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society for Sexual Medicine and Andrology
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623530/ https://www.ncbi.nlm.nih.gov/pubmed/23596605 http://dx.doi.org/10.5534/wjmh.2012.30.3.153 |
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author | Park, Yeon Won Kim, Yooseok Lee, Jun Ho |
author_facet | Park, Yeon Won Kim, Yooseok Lee, Jun Ho |
author_sort | Park, Yeon Won |
collection | PubMed |
description | Sexual dysfunction is a common condition in patients taking antipsychotics, and is the most bothersome symptom and adverse drug effect, resulting in a negative effect on treatment compliance. It is known that hyperprolactinemia is a major cause of sexual dysfunction. Based on the blockade of dopamine D2 receptors, haloperidol, risperidone, and amisulpride are classed as prolactin-elevating antipsychotics, while olanzapine, clozapine, quetiapine, ziprasidone, and aripiprazole are classed as prolactin-sparing drugs. Risperidone and the other typical antipsychotics are associated with a high rate of sexual dysfunction as compared to olanzapine, clozapine, quetiapine, and aripiprazole. With regard to treatment in patients suffering from sexual dysfunction, sildenafil was associated with significantly more erections sufficient for penetration as compared to a placebo. Subsequent studies are needed in order to provide physicians with a better understanding of this problem, thereby leading toward efficacious and safe solutions. |
format | Online Article Text |
id | pubmed-3623530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Korean Society for Sexual Medicine and Andrology |
record_format | MEDLINE/PubMed |
spelling | pubmed-36235302013-04-17 Antipsychotic-Induced Sexual Dysfunction and Its Management Park, Yeon Won Kim, Yooseok Lee, Jun Ho World J Mens Health Review Article Sexual dysfunction is a common condition in patients taking antipsychotics, and is the most bothersome symptom and adverse drug effect, resulting in a negative effect on treatment compliance. It is known that hyperprolactinemia is a major cause of sexual dysfunction. Based on the blockade of dopamine D2 receptors, haloperidol, risperidone, and amisulpride are classed as prolactin-elevating antipsychotics, while olanzapine, clozapine, quetiapine, ziprasidone, and aripiprazole are classed as prolactin-sparing drugs. Risperidone and the other typical antipsychotics are associated with a high rate of sexual dysfunction as compared to olanzapine, clozapine, quetiapine, and aripiprazole. With regard to treatment in patients suffering from sexual dysfunction, sildenafil was associated with significantly more erections sufficient for penetration as compared to a placebo. Subsequent studies are needed in order to provide physicians with a better understanding of this problem, thereby leading toward efficacious and safe solutions. Korean Society for Sexual Medicine and Andrology 2012-12 2012-12-27 /pmc/articles/PMC3623530/ /pubmed/23596605 http://dx.doi.org/10.5534/wjmh.2012.30.3.153 Text en Copyright © 2012 Korean Society for Sexual Medicine and Andrology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Park, Yeon Won Kim, Yooseok Lee, Jun Ho Antipsychotic-Induced Sexual Dysfunction and Its Management |
title | Antipsychotic-Induced Sexual Dysfunction and Its Management |
title_full | Antipsychotic-Induced Sexual Dysfunction and Its Management |
title_fullStr | Antipsychotic-Induced Sexual Dysfunction and Its Management |
title_full_unstemmed | Antipsychotic-Induced Sexual Dysfunction and Its Management |
title_short | Antipsychotic-Induced Sexual Dysfunction and Its Management |
title_sort | antipsychotic-induced sexual dysfunction and its management |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623530/ https://www.ncbi.nlm.nih.gov/pubmed/23596605 http://dx.doi.org/10.5534/wjmh.2012.30.3.153 |
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