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Antipsychotic-Induced Sexual Dysfunction and Its Management

Sexual dysfunction is a common condition in patients taking antipsychotics, and is the most bothersome symptom and adverse drug effect, resulting in a negative effect on treatment compliance. It is known that hyperprolactinemia is a major cause of sexual dysfunction. Based on the blockade of dopamin...

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Autores principales: Park, Yeon Won, Kim, Yooseok, Lee, Jun Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Sexual Medicine and Andrology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623530/
https://www.ncbi.nlm.nih.gov/pubmed/23596605
http://dx.doi.org/10.5534/wjmh.2012.30.3.153
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author Park, Yeon Won
Kim, Yooseok
Lee, Jun Ho
author_facet Park, Yeon Won
Kim, Yooseok
Lee, Jun Ho
author_sort Park, Yeon Won
collection PubMed
description Sexual dysfunction is a common condition in patients taking antipsychotics, and is the most bothersome symptom and adverse drug effect, resulting in a negative effect on treatment compliance. It is known that hyperprolactinemia is a major cause of sexual dysfunction. Based on the blockade of dopamine D2 receptors, haloperidol, risperidone, and amisulpride are classed as prolactin-elevating antipsychotics, while olanzapine, clozapine, quetiapine, ziprasidone, and aripiprazole are classed as prolactin-sparing drugs. Risperidone and the other typical antipsychotics are associated with a high rate of sexual dysfunction as compared to olanzapine, clozapine, quetiapine, and aripiprazole. With regard to treatment in patients suffering from sexual dysfunction, sildenafil was associated with significantly more erections sufficient for penetration as compared to a placebo. Subsequent studies are needed in order to provide physicians with a better understanding of this problem, thereby leading toward efficacious and safe solutions.
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spelling pubmed-36235302013-04-17 Antipsychotic-Induced Sexual Dysfunction and Its Management Park, Yeon Won Kim, Yooseok Lee, Jun Ho World J Mens Health Review Article Sexual dysfunction is a common condition in patients taking antipsychotics, and is the most bothersome symptom and adverse drug effect, resulting in a negative effect on treatment compliance. It is known that hyperprolactinemia is a major cause of sexual dysfunction. Based on the blockade of dopamine D2 receptors, haloperidol, risperidone, and amisulpride are classed as prolactin-elevating antipsychotics, while olanzapine, clozapine, quetiapine, ziprasidone, and aripiprazole are classed as prolactin-sparing drugs. Risperidone and the other typical antipsychotics are associated with a high rate of sexual dysfunction as compared to olanzapine, clozapine, quetiapine, and aripiprazole. With regard to treatment in patients suffering from sexual dysfunction, sildenafil was associated with significantly more erections sufficient for penetration as compared to a placebo. Subsequent studies are needed in order to provide physicians with a better understanding of this problem, thereby leading toward efficacious and safe solutions. Korean Society for Sexual Medicine and Andrology 2012-12 2012-12-27 /pmc/articles/PMC3623530/ /pubmed/23596605 http://dx.doi.org/10.5534/wjmh.2012.30.3.153 Text en Copyright © 2012 Korean Society for Sexual Medicine and Andrology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Park, Yeon Won
Kim, Yooseok
Lee, Jun Ho
Antipsychotic-Induced Sexual Dysfunction and Its Management
title Antipsychotic-Induced Sexual Dysfunction and Its Management
title_full Antipsychotic-Induced Sexual Dysfunction and Its Management
title_fullStr Antipsychotic-Induced Sexual Dysfunction and Its Management
title_full_unstemmed Antipsychotic-Induced Sexual Dysfunction and Its Management
title_short Antipsychotic-Induced Sexual Dysfunction and Its Management
title_sort antipsychotic-induced sexual dysfunction and its management
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623530/
https://www.ncbi.nlm.nih.gov/pubmed/23596605
http://dx.doi.org/10.5534/wjmh.2012.30.3.153
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