Warm Autoimmune Hemolytic Anemia with a Direct Antiglobulin Test Positive for C3 and Negative for IgG: A Case Study and Analytical Literature Review of Incidence and Severity

Polygenic IgG autoantibodies are implicated in majority of the cases of warm autoimmune hemolytic anemia (WAIHA). In some of these cases, complement (C3) proteins accompany the IgG antibodies. WAIHA mediated by C3 alone is relatively rare. We present an interesting case of WAIHA with a direct antigl...

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Detalles Bibliográficos
Autores principales: Palla, Amruth R., Khimani, Farhad, Craig, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623608/
https://www.ncbi.nlm.nih.gov/pubmed/23645992
http://dx.doi.org/10.4137/CCRep.S11469
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author Palla, Amruth R.
Khimani, Farhad
Craig, Michael D.
author_facet Palla, Amruth R.
Khimani, Farhad
Craig, Michael D.
author_sort Palla, Amruth R.
collection PubMed
description Polygenic IgG autoantibodies are implicated in majority of the cases of warm autoimmune hemolytic anemia (WAIHA). In some of these cases, complement (C3) proteins accompany the IgG antibodies. WAIHA mediated by C3 alone is relatively rare. We present an interesting case of WAIHA with a direct antiglobulin test (DAT) positive for C3 but negative for IgG in a 79-year-old woman and perform an analytical literature review of the incidence and severity of this clinical entity.
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spelling pubmed-36236082013-05-03 Warm Autoimmune Hemolytic Anemia with a Direct Antiglobulin Test Positive for C3 and Negative for IgG: A Case Study and Analytical Literature Review of Incidence and Severity Palla, Amruth R. Khimani, Farhad Craig, Michael D. Clin Med Insights Case Rep Case Report Polygenic IgG autoantibodies are implicated in majority of the cases of warm autoimmune hemolytic anemia (WAIHA). In some of these cases, complement (C3) proteins accompany the IgG antibodies. WAIHA mediated by C3 alone is relatively rare. We present an interesting case of WAIHA with a direct antiglobulin test (DAT) positive for C3 but negative for IgG in a 79-year-old woman and perform an analytical literature review of the incidence and severity of this clinical entity. Libertas Academica 2013-04-02 /pmc/articles/PMC3623608/ /pubmed/23645992 http://dx.doi.org/10.4137/CCRep.S11469 Text en © 2013 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited.
spellingShingle Case Report
Palla, Amruth R.
Khimani, Farhad
Craig, Michael D.
Warm Autoimmune Hemolytic Anemia with a Direct Antiglobulin Test Positive for C3 and Negative for IgG: A Case Study and Analytical Literature Review of Incidence and Severity
title Warm Autoimmune Hemolytic Anemia with a Direct Antiglobulin Test Positive for C3 and Negative for IgG: A Case Study and Analytical Literature Review of Incidence and Severity
title_full Warm Autoimmune Hemolytic Anemia with a Direct Antiglobulin Test Positive for C3 and Negative for IgG: A Case Study and Analytical Literature Review of Incidence and Severity
title_fullStr Warm Autoimmune Hemolytic Anemia with a Direct Antiglobulin Test Positive for C3 and Negative for IgG: A Case Study and Analytical Literature Review of Incidence and Severity
title_full_unstemmed Warm Autoimmune Hemolytic Anemia with a Direct Antiglobulin Test Positive for C3 and Negative for IgG: A Case Study and Analytical Literature Review of Incidence and Severity
title_short Warm Autoimmune Hemolytic Anemia with a Direct Antiglobulin Test Positive for C3 and Negative for IgG: A Case Study and Analytical Literature Review of Incidence and Severity
title_sort warm autoimmune hemolytic anemia with a direct antiglobulin test positive for c3 and negative for igg: a case study and analytical literature review of incidence and severity
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623608/
https://www.ncbi.nlm.nih.gov/pubmed/23645992
http://dx.doi.org/10.4137/CCRep.S11469
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AT khimanifarhad warmautoimmunehemolyticanemiawithadirectantiglobulintestpositiveforc3andnegativeforiggacasestudyandanalyticalliteraturereviewofincidenceandseverity
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