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Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression?
Metazoan cells rapidly exchange signals at tight cell–cell interfaces, including synapses and gap junctions. Advances in imaging recently exposed a third mode of intercellular cross-talk mediated by thin, actin-containing membrane extensions broadly known as “membrane” or “tunneling” nanotubes. An e...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The American Society for Cell Biology
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623630/ https://www.ncbi.nlm.nih.gov/pubmed/23580190 http://dx.doi.org/10.1091/mbc.E12-08-0622 |
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author | Sherer, Nathan M. |
author_facet | Sherer, Nathan M. |
author_sort | Sherer, Nathan M. |
collection | PubMed |
description | Metazoan cells rapidly exchange signals at tight cell–cell interfaces, including synapses and gap junctions. Advances in imaging recently exposed a third mode of intercellular cross-talk mediated by thin, actin-containing membrane extensions broadly known as “membrane” or “tunneling” nanotubes. An explosion of research suggests diverse functions for nanotubular superhighways, including cell–cell electrical coupling, calcium signaling, small-molecule exchange, and, remarkably, the transfer of bulky cargoes, including organelles or pathogenic agents. Despite great enthusiasm for all things nanotubular and their potential roles in cell signaling and pathogenesis, key questions remain regarding the mechanisms by which these structures regulate directional cell–cell exchange; how these linkages are formed and between which cells and, critically, whether nanotubes are as prevalent in vivo as they appear to be in the incubator. |
format | Online Article Text |
id | pubmed-3623630 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The American Society for Cell Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-36236302013-06-30 Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression? Sherer, Nathan M. Mol Biol Cell Perspectives Metazoan cells rapidly exchange signals at tight cell–cell interfaces, including synapses and gap junctions. Advances in imaging recently exposed a third mode of intercellular cross-talk mediated by thin, actin-containing membrane extensions broadly known as “membrane” or “tunneling” nanotubes. An explosion of research suggests diverse functions for nanotubular superhighways, including cell–cell electrical coupling, calcium signaling, small-molecule exchange, and, remarkably, the transfer of bulky cargoes, including organelles or pathogenic agents. Despite great enthusiasm for all things nanotubular and their potential roles in cell signaling and pathogenesis, key questions remain regarding the mechanisms by which these structures regulate directional cell–cell exchange; how these linkages are formed and between which cells and, critically, whether nanotubes are as prevalent in vivo as they appear to be in the incubator. The American Society for Cell Biology 2013-04-15 /pmc/articles/PMC3623630/ /pubmed/23580190 http://dx.doi.org/10.1091/mbc.E12-08-0622 Text en © 2013 Sherer. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell BD; are registered trademarks of The American Society of Cell Biology. |
spellingShingle | Perspectives Sherer, Nathan M. Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression? |
title | Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression? |
title_full | Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression? |
title_fullStr | Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression? |
title_full_unstemmed | Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression? |
title_short | Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression? |
title_sort | long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression? |
topic | Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623630/ https://www.ncbi.nlm.nih.gov/pubmed/23580190 http://dx.doi.org/10.1091/mbc.E12-08-0622 |
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