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Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression?

Metazoan cells rapidly exchange signals at tight cell–cell interfaces, including synapses and gap junctions. Advances in imaging recently exposed a third mode of intercellular cross-talk mediated by thin, actin-containing membrane extensions broadly known as “membrane” or “tunneling” nanotubes. An e...

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Detalles Bibliográficos
Autor principal: Sherer, Nathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623630/
https://www.ncbi.nlm.nih.gov/pubmed/23580190
http://dx.doi.org/10.1091/mbc.E12-08-0622
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author Sherer, Nathan M.
author_facet Sherer, Nathan M.
author_sort Sherer, Nathan M.
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description Metazoan cells rapidly exchange signals at tight cell–cell interfaces, including synapses and gap junctions. Advances in imaging recently exposed a third mode of intercellular cross-talk mediated by thin, actin-containing membrane extensions broadly known as “membrane” or “tunneling” nanotubes. An explosion of research suggests diverse functions for nanotubular superhighways, including cell–cell electrical coupling, calcium signaling, small-molecule exchange, and, remarkably, the transfer of bulky cargoes, including organelles or pathogenic agents. Despite great enthusiasm for all things nanotubular and their potential roles in cell signaling and pathogenesis, key questions remain regarding the mechanisms by which these structures regulate directional cell–cell exchange; how these linkages are formed and between which cells and, critically, whether nanotubes are as prevalent in vivo as they appear to be in the incubator.
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spelling pubmed-36236302013-06-30 Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression? Sherer, Nathan M. Mol Biol Cell Perspectives Metazoan cells rapidly exchange signals at tight cell–cell interfaces, including synapses and gap junctions. Advances in imaging recently exposed a third mode of intercellular cross-talk mediated by thin, actin-containing membrane extensions broadly known as “membrane” or “tunneling” nanotubes. An explosion of research suggests diverse functions for nanotubular superhighways, including cell–cell electrical coupling, calcium signaling, small-molecule exchange, and, remarkably, the transfer of bulky cargoes, including organelles or pathogenic agents. Despite great enthusiasm for all things nanotubular and their potential roles in cell signaling and pathogenesis, key questions remain regarding the mechanisms by which these structures regulate directional cell–cell exchange; how these linkages are formed and between which cells and, critically, whether nanotubes are as prevalent in vivo as they appear to be in the incubator. The American Society for Cell Biology 2013-04-15 /pmc/articles/PMC3623630/ /pubmed/23580190 http://dx.doi.org/10.1091/mbc.E12-08-0622 Text en © 2013 Sherer. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell BD; are registered trademarks of The American Society of Cell Biology.
spellingShingle Perspectives
Sherer, Nathan M.
Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression?
title Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression?
title_full Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression?
title_fullStr Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression?
title_full_unstemmed Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression?
title_short Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression?
title_sort long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression?
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623630/
https://www.ncbi.nlm.nih.gov/pubmed/23580190
http://dx.doi.org/10.1091/mbc.E12-08-0622
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