Cargando…

Senataxin Plays an Essential Role with DNA Damage Response Proteins in Meiotic Recombination and Gene Silencing

Senataxin, mutated in the human genetic disorder ataxia with oculomotor apraxia type 2 (AOA2), plays an important role in maintaining genome integrity by coordination of transcription, DNA replication, and the DNA damage response. We demonstrate that senataxin is essential for spermatogenesis and th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Becherel, Olivier J., Yeo, Abrey J., Stellati, Alissa, Heng, Evelyn Y. H., Luff, John, Suraweera, Amila M., Woods, Rick, Fleming, Jean, Carrie, Dianne, McKinney, Kristine, Xu, Xiaoling, Deng, Chuxia, Lavin, Martin F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623790/ https://www.ncbi.nlm.nih.gov/pubmed/23593030 http://dx.doi.org/10.1371/journal.pgen.1003435

Ejemplares similares

Senataxin controls meiotic silencing through ATR activation and chromatin remodeling
por: Yeo, Abrey J, et al.
Publicado: (2015)

Senataxin protects the genome: Implications for neurodegeneration and other abnormalities
por: Lavin, Martin F., et al.
Publicado: (2013)

Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage
por: Suraweera, Amila, et al.
Publicado: (2007)

Effects of senataxin and RNA exosome on B-cell chromosomal integrity
por: Kazadi, David, et al.
Publicado: (2020)

The helicase senataxin suppresses the antiviral transcriptional response and controls viral biogenesis
por: Miller, Matthew S., et al.
Publicado: (2015)

R-Loops in Proliferating Cells but Not in the Brain: Implications for AOA2 and Other Autosomal Recessive Ataxias
por: Yeo, Abrey J., et al.
Publicado: (2014)

Regulating autophagy: a novel role for SETX (Senataxin)
por: Richard, Patricia, et al.
Publicado: (2021)

Senataxin and R-loops homeostasis: multifaced implications in carcinogenesis
por: Gatti, Veronica, et al.
Publicado: (2023)

USP11 controls R-loops by regulating senataxin proteostasis
por: Jurga, Mateusz, et al.
Publicado: (2021)

Suppressors of Meiotic Silencing by Unpaired DNA
por: Xiao, Hua, et al.
Publicado: (2019)

Meiotic Silencing in Dothideomycetous Bipolaris maydis
por: Tsuji, Kenya, et al.
Publicado: (2022)

Clinical and Molecular Aspects of Senataxin Mutations in Amyotrophic Lateral Sclerosis 4
por: Grunseich, Christopher, et al.
Publicado: (2020)

Editorial: Cancer Therapeutics: Targeting DNA Repair Pathways
por: Suraweera, Amila, et al.
Publicado: (2022)

Hereditary Ataxia with a Novel Mutation in the Senataxin Gene: A Case Report
por: Moghanloo, Ehsan, et al.
Publicado: (2019)

Senataxin: A New Guardian of the Female Germline Important for Delaying Ovarian Aging
por: Homer, Hayden A.
Publicado: (2021)

Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation
por: Mahadevaiah, Shantha K., et al.
Publicado: (2008)

Protein Interaction Analysis of Senataxin and the ALS4 L389S Mutant Yields Insights into Senataxin Post-Translational Modification and Uncovers Mutant-Specific Binding with a Brain Cytoplasmic RNA-Encoded Peptide
por: Bennett, Craig L., et al.
Publicado: (2013)

Aberrant Splicing of the Senataxin Gene in a Patient with Ataxia with Oculomotor Apraxia Type 2
por: Fogel, Brent L., et al.
Publicado: (2009)

Mutation in senataxin alters the mechanism of R-loop resolution in amyotrophic lateral sclerosis 4
por: Kannan, Annapoorna, et al.
Publicado: (2022)

Mammalian meiotic silencing exhibits sexually dimorphic features
por: Cloutier, J. M., et al.
Publicado: (2015)

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations
por: Cohen, Sarah, et al.
Publicado: (2018)

A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links
por: Andrews, Alex M., et al.
Publicado: (2018)

Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factor
por: Hasanova, Zdenka, et al.
Publicado: (2023)

Involvement of RNA granule proteins in meiotic silencing by unpaired DNA
por: Xiao, Hua, et al.
Publicado: (2021)

Senataxin Associates with Replication Forks to Protect Fork Integrity across RNA-Polymerase-II-Transcribed Genes
por: Alzu, Amaya, et al.
Publicado: (2012)

Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy
por: Kannan, Annapoorna, et al.
Publicado: (2018)

ΔNp63-Senataxin circuit controls keratinocyte differentiation by promoting the transcriptional termination of epidermal genes
por: Gatti, Veronica, et al.
Publicado: (2022)

Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination
por: Zhao, Hongchang, et al.
Publicado: (2022)

Meiotic silencing and fragmentation of the male germline restricted chromosome in zebra finch
por: Schoenmakers, Sam, et al.
Publicado: (2010)

SPO11-Independent DNA Repair Foci and Their Role in Meiotic Silencing
por: Carofiglio, Fabrizia, et al.
Publicado: (2013)

Silencing of X-Linked MicroRNAs by Meiotic Sex Chromosome Inactivation
por: Royo, Hélène, et al.
Publicado: (2015)

The Nuclear Cap-Binding Complex Mediates Meiotic Silencing by Unpaired DNA
por: Decker, Logan M., et al.
Publicado: (2017)

An NCBP3-Domain Protein Mediates Meiotic Silencing by Unpaired DNA
por: Boone, Erin C., et al.
Publicado: (2020)

Corrigendum to: Involvement of RNA granule proteins in meiotic silencing by unpaired DNA
por: Xiao, Hua, et al.
Publicado: (2021)

Identification of novel senataxin mutations in Chinese patients with autosomal recessive cerebellar ataxias by targeted next-generation sequencing
por: Lu, Cong, et al.
Publicado: (2016)

Metabolic Stress and Mitochondrial Dysfunction in Ataxia-Telangiectasia
por: Subramanian, Goutham Narayanan, et al.
Publicado: (2022)

Dynamics of Response to Asynapsis and Meiotic Silencing in Spermatocytes from Robertsonian Translocation Carriers
por: Naumova, Anna K., et al.
Publicado: (2013)

Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex
por: Egan, Emily D., et al.
Publicado: (2014)

ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing
por: Royo, Hélène, et al.
Publicado: (2013)

Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon
por: Wang, Yizhou, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_unhvl511ss6a7e6b9ldcqa6bvi