Proteomic and functional annotation analysis of injured peripheral nerves reveals ApoE as a protein upregulated by injury that is modulated by metformin treatment

BACKGROUND: Peripheral nerve injury (PNI) results in a fundamental reorganization of the translational machinery in the injured peripheral nerve such that protein synthesis is increased in a manner linked to enhanced mTOR and ERK activity. We have shown that metformin treatment, which activates aden...

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Detalles Bibliográficos
Autores principales: Melemedjian, Ohannes K, Yassine, Hussein N, Shy, Adia, Price, Theodore J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623807/
https://www.ncbi.nlm.nih.gov/pubmed/23531341
http://dx.doi.org/10.1186/1744-8069-9-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623807/
https://www.ncbi.nlm.nih.gov/pubmed/23531341
http://dx.doi.org/10.1186/1744-8069-9-14

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