A new unique form of microRNA from human heart, microRNA-499c, promotes myofibril formation and rescues cardiac development in mutant axolotl embryos

BACKGROUND: A recessive mutation “c” in the Mexican axolotl, Ambystoma mexicanum, results in the failure of normal heart development. In homozygous recessive embryos, the hearts do not have organized myofibrils and fail to beat. In our previous studies, we identified a noncoding Myofibril-Inducing R...

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Detalles Bibliográficos
Autores principales: Kochegarov, Andrei, Moses, Ashley, Lian, William, Meyer, Jessica, Hanna, Michael C, Lemanski, Larry F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623845/
https://www.ncbi.nlm.nih.gov/pubmed/23522091
http://dx.doi.org/10.1186/1423-0127-20-20

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