High resolution melting analysis of KRAS, BRAF and PIK3CA in KRAS exon 2 wild-type metastatic colorectal cancer

BACKGROUND: KRAS is an EGFR effector in the RAS/RAF/ERK cascade that is mutated in about 40% of metastatic colorectal cancer (mCRC). Activating mutations in codons 12 and 13 of the KRAS gene are the only established negative predictors of response to anti-EGFR therapy and patients whose tumors harbo...

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Detalles Bibliográficos
Autores principales: Guedes, Joana G, Veiga, Isabel, Rocha, Patrícia, Pinto, Pedro, Pinto, Carla, Pinheiro, Manuela, Peixoto, Ana, Fragoso, Maria, Raimundo, Ana, Ferreira, Paula, Machado, Manuela, Sousa, Nuno, Lopes, Paula, Araújo, António, Macedo, Joana, Alves, Fernando, Coutinho, Camila, Henrique, Rui, Santos, Lúcio L, Teixeira, Manuel R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623853/
https://www.ncbi.nlm.nih.gov/pubmed/23548132
http://dx.doi.org/10.1186/1471-2407-13-169

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