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Stim1, PKCδ and RasGRP proteins set a threshold for pro-apoptotic Erk signaling during B cell development
Clonal deletion of autoreactive B cells is crucial to prevent autoimmunity, but the signaling mechanisms that regulate this checkpoint remain undefined. Here we characterized a previously unrecognized Ca(2+)-driven Erk activation pathway, which was pro-apoptotic and biochemically distinct from DAG-i...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623929/ https://www.ncbi.nlm.nih.gov/pubmed/21441934 http://dx.doi.org/10.1038/ni.2016 |