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White-Matter Changes Correlate with Cognitive Functioning in Parkinson’s Disease

Diffusion tensor imaging (DTI) findings from emerging studies of cortical white-matter integrity in Parkinson’s disease (PD) without dementia are inconclusive. When white-matter changes have been found, their relationship to cognitive functioning in PD has not been carefully investigated. To better...

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Autores principales: Theilmann, Rebecca J., Reed, Jason D., Song, David D., Huang, Mingxiong X., Lee, Roland R., Litvan, Irene, Harrington, Deborah L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624087/
https://www.ncbi.nlm.nih.gov/pubmed/23630517
http://dx.doi.org/10.3389/fneur.2013.00037
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author Theilmann, Rebecca J.
Reed, Jason D.
Song, David D.
Huang, Mingxiong X.
Lee, Roland R.
Litvan, Irene
Harrington, Deborah L.
author_facet Theilmann, Rebecca J.
Reed, Jason D.
Song, David D.
Huang, Mingxiong X.
Lee, Roland R.
Litvan, Irene
Harrington, Deborah L.
author_sort Theilmann, Rebecca J.
collection PubMed
description Diffusion tensor imaging (DTI) findings from emerging studies of cortical white-matter integrity in Parkinson’s disease (PD) without dementia are inconclusive. When white-matter changes have been found, their relationship to cognitive functioning in PD has not been carefully investigated. To better characterize changes in tissue diffusivity and to understand their functional significance, the present study conducted DTI in 25 PD patients without dementia and 26 controls of similar ages. An automated tract-based DTI method was used. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were analyzed. Neuropsychological measures of executive functioning (working memory, verbal fluency, cognitive flexibility, inhibitory control) and visuospatial ability were then correlated with regions of interest that showed abnormal diffusivity in the PD group. We found widespread reductions in FA and increases in MD in the PD group relative to controls. These changes were predominantly related to an increase in RD. Increased AD in the PD group was limited to specific frontal tracks of the right hemisphere, possibly signifying more significant tissue changes. Motor symptom severity did not correlate with FA. However, different measures of executive functioning and visuospatial ability correlated with FA in different segments of tracts, which contain fiber pathways to cortical regions that are thought to support specific cognitive processes. The findings suggest that abnormal tissue diffusivity may be sensitive to subtle cognitive changes in PD, some of which may be prognostic of future cognitive decline.
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spelling pubmed-36240872013-04-29 White-Matter Changes Correlate with Cognitive Functioning in Parkinson’s Disease Theilmann, Rebecca J. Reed, Jason D. Song, David D. Huang, Mingxiong X. Lee, Roland R. Litvan, Irene Harrington, Deborah L. Front Neurol Neuroscience Diffusion tensor imaging (DTI) findings from emerging studies of cortical white-matter integrity in Parkinson’s disease (PD) without dementia are inconclusive. When white-matter changes have been found, their relationship to cognitive functioning in PD has not been carefully investigated. To better characterize changes in tissue diffusivity and to understand their functional significance, the present study conducted DTI in 25 PD patients without dementia and 26 controls of similar ages. An automated tract-based DTI method was used. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were analyzed. Neuropsychological measures of executive functioning (working memory, verbal fluency, cognitive flexibility, inhibitory control) and visuospatial ability were then correlated with regions of interest that showed abnormal diffusivity in the PD group. We found widespread reductions in FA and increases in MD in the PD group relative to controls. These changes were predominantly related to an increase in RD. Increased AD in the PD group was limited to specific frontal tracks of the right hemisphere, possibly signifying more significant tissue changes. Motor symptom severity did not correlate with FA. However, different measures of executive functioning and visuospatial ability correlated with FA in different segments of tracts, which contain fiber pathways to cortical regions that are thought to support specific cognitive processes. The findings suggest that abnormal tissue diffusivity may be sensitive to subtle cognitive changes in PD, some of which may be prognostic of future cognitive decline. Frontiers Media S.A. 2013-04-12 /pmc/articles/PMC3624087/ /pubmed/23630517 http://dx.doi.org/10.3389/fneur.2013.00037 Text en Copyright © 2013 Theilmann, Reed, Song, Huang, Lee, Litvan and Harrington. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
Theilmann, Rebecca J.
Reed, Jason D.
Song, David D.
Huang, Mingxiong X.
Lee, Roland R.
Litvan, Irene
Harrington, Deborah L.
White-Matter Changes Correlate with Cognitive Functioning in Parkinson’s Disease
title White-Matter Changes Correlate with Cognitive Functioning in Parkinson’s Disease
title_full White-Matter Changes Correlate with Cognitive Functioning in Parkinson’s Disease
title_fullStr White-Matter Changes Correlate with Cognitive Functioning in Parkinson’s Disease
title_full_unstemmed White-Matter Changes Correlate with Cognitive Functioning in Parkinson’s Disease
title_short White-Matter Changes Correlate with Cognitive Functioning in Parkinson’s Disease
title_sort white-matter changes correlate with cognitive functioning in parkinson’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624087/
https://www.ncbi.nlm.nih.gov/pubmed/23630517
http://dx.doi.org/10.3389/fneur.2013.00037
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