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Metabolome Response to Glucose in the β-Cell Line INS-1 832/13

Glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells is triggered by metabolism of the sugar to increase ATP/ADP ratio that blocks the K(ATP) channel leading to membrane depolarization and insulin exocytosis. Other metabolic pathways believed to augment insulin secretion have yet to b...

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Detalles Bibliográficos
Autores principales:	Lorenz, Matthew A., El Azzouny, Mahmoud A., Kennedy, Robert T., Burant, Charles F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624472/ https://www.ncbi.nlm.nih.gov/pubmed/23426361 http://dx.doi.org/10.1074/jbc.M112.414961

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