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Role of PI3K-AKT-mTOR and Wnt Signaling Pathways in Transition of G1-S Phase of Cell Cycle in Cancer Cells

The PI3K-Akt pathway together with one of its downstream targets, the mechanistic target of rapamycin (mTOR; also known as the mammalian target of rapamycin) is a highly deregulated pathway in cancers. mTOR exists in two complexes, mTORC1 and mTORC2. Akt phosphorylated at T308 inhibits TSC1/2 comple...

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Detalles Bibliográficos
Autores principales:	Vadlakonda, Lakshmipathi, Pasupuleti, Mukesh, Pallu, Reddanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624606/ https://www.ncbi.nlm.nih.gov/pubmed/23596569 http://dx.doi.org/10.3389/fonc.2013.00085

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